Nebulin, a multi-functional giant

The Journal of Experimental Biology
Miensheng ChuChristopher T Pappas

Abstract

Efficient muscle contraction in skeletal muscle is predicated on the regulation of actin filament lengths. In one long-standing model that was prominent for decades, the giant protein nebulin was proposed to function as a 'molecular ruler' to specify the lengths of the thin filaments. This theory was questioned by many observations, including experiments in which the length of nebulin was manipulated in skeletal myocytes; this approach revealed that nebulin functions to stabilize filamentous actin, allowing thin filaments to reach mature lengths. In addition, more recent data, mostly from in vivo models and identification of new interacting partners, have provided evidence that nebulin is not merely a structural protein. Nebulin plays a role in numerous cellular processes including regulation of muscle contraction, Z-disc formation, and myofibril organization and assembly.

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Citations

Oct 14, 2016·Molecular Biology of the Cell·Daniel A HernandezGloria M Conover
Jan 23, 2016·The Journal of Experimental Biology·Mathias Gautel, Kristina Djinović-Carugo
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Jul 15, 2021·Nature Reviews. Molecular Cell Biology·James J DowlingMelissa J Spencer

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