PMID: 9536832Apr 16, 1998Paper

Nebulisation of surfactants in an animal model of neonatal respiratory distress

Archives of Disease in Childhood. Fetal and Neonatal Edition
T F FokH Kirpalani

Abstract

To evaluate pulmonary deposition and gas exchange following nebulisation of two surfactants by either a jet or an ultrasonic nebuliser. After bronchoalveolar lavage (BAL), 19 rabbits were ventilated in four groups. Group A1 (n = 5) and A2 (n = 6) received Technetium-99m labelled Exosurf, and groups B1 (n = 4) and B2 (n = 4) received radiolabelled Survanta. Groups A1 and B1 received jet nebuliser therapy, whereas groups A2 and B2 received ultrasonic nebuliser. Pulmonary deposition, distribution, and blood gases were determined. Pulmonary deposition as per cent of initial dose and mg lipid) was 0.28(0.10)% or 0.59(0.21) mg in group A1, 1.05(0.23)% or 2.21(0.48) mg in group A2, 0.08(0.02)% or 0.30(0.08) mg in group B1, and 0.09(0.02)% or 0.34(0.08) mg in group B2. Deposition in group A2 was greater than in other groups (p = 0.001). Group A2 showed a small improvement in blood gases. Even the highest deposition--ultrasonic nebuliser with Exosurf--achieved limited clinical effect. The aerosol route is currently not effective for surfactant treatment.

References

Jan 1, 1992·Archives of Disease in Childhood·J GriggM Silverman
Jan 1, 1991·Pediatric Pulmonology·D CameronM Silverman
Oct 1, 1991·Archives of Disease in Childhood·F CowanM Silverman
Jan 1, 1991·Pediatric Pulmonology·K L WatterbergS Murphy
Feb 1, 1990·The American Review of Respiratory Disease·H D FullerM T Newhouse
Aug 1, 1990·Critical Care Medicine·D CameronM Silverman
Jan 1, 1986·Pediatric Pulmonology·M FlavinH O'Brodovich
Feb 1, 1985·Critical Care Medicine·N R MacIntyreR E Coleman
Nov 9, 1994·JAMA : the Journal of the American Medical Association·J G WegE N Pattishall
Jan 1, 1994·Acta Anaesthesiologica Scandinavica·W Z LiT Kobayashi
Oct 1, 1993·The American Review of Respiratory Disease·S H ThomasT O Nunan
Nov 1, 1993·The American Review of Respiratory Disease·J F Lewis, L McCaig
Apr 1, 1997·American Journal of Respiratory and Critical Care Medicine·T J GregoryA J Gold

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Citations

Jan 15, 2004·American Journal of Respiratory Medicine : Drugs, Devices, and Other Interventions·Sean B Ainsworth, David W A Milligan
Jul 5, 2003·Advanced Drug Delivery Reviews·Mark L Everard
Mar 21, 2000·Biophysical Chemistry·M H WagnerU Boenick
Feb 27, 2001·Early Human Development·A E Curley, H L Halliday
Dec 18, 2012·Critical Care Research and Practice·Samir Gupta, Steven M Donn
Jul 29, 2003·American Journal of Respiratory and Critical Care Medicine·Yong-Zheng WuLhousseine Touqui
Apr 26, 2013·Expert Opinion on Drug Delivery·James Fink, Arzu Ari
Sep 26, 2001·Clinics in Perinatology·G K Suresh, R F Soll
Feb 18, 2016·Aerosol Science and Technology : the Journal of the American Association for Aerosol Research·Zeeshan H SyedainArif Somani
Nov 14, 2016·Clinics in Perinatology·Angela Kribs
Apr 30, 2005·Journal of Perinatology : Official Journal of the California Perinatal Association·Gautham K Suresh, Roger F Soll
Jul 26, 2017·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Ilaria MilesiRaffaele L Dellaca'
Mar 20, 2004·Pediatric Pulmonology. Supplement·Henry L Halliday
Oct 19, 2012·The Cochrane Database of Systematic Reviews·Mohamed E Abdel-Latif, David A Osborn
Feb 18, 2012·The Cochrane Database of Systematic Reviews·Kenneth TanAjay Sharma
Oct 19, 2017·Korean journal of pediatrics·Gyu-Hong Shim
Aug 2, 2000·Critical Care Medicine·M H WagnerM Obladen
Mar 21, 2020·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Carmen Rey-SantanoBegoña Loureiro
Mar 27, 1999·Pediatric Pulmonology. Supplement·M Dolovich
Apr 29, 2000·Acta Anaesthesiologica Scandinavica·H BahlmannB Robertson
Feb 20, 2021·Critical Care Explorations·Robert M DiBlasiMichael A Portman
Jul 3, 2021·Children·Mandy BrasherElie G Abu Jawdeh

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