PMID: 2111980Apr 1, 1990Paper

Nebulised sodium cromoglycate in infancy: airway protection after deterioration

Archives of Disease in Childhood
C O'CallaghanA Swarbrick

Abstract

Over a two year period 100 infants with histories of wheeze were challenged with nebulised water. They were sedated and lung function measured by total body plethysmography. Thirteen of the 53 infants who developed bronchoconstriction after challenge with nebulised water were given nebulised sodium cromoglycate and rechallenged with nebulised water. All infants were initially challenged with normal saline, after which there was no significant change in lung function. After challenge with nebulised water and sodium cromoglycate there were significant decreases in specific conductance compared with those found after challenge with normal saline. After rechallenge with nebulised water there was no deterioration in lung function. Although sodium cromoglycate caused a deterioration in lung function in these infants, it protected their airways from challenge with nebulised water.

References

Jan 1, 1977·International Archives of Allergy and Applied Immunology·C P SungL W Chakrin
Oct 27, 1979·British Medical Journal·J T Chung, R S Jones
Jan 1, 1985·Allergy·R J ShawA B Kay
May 1, 1988·Archives of Disease in Childhood·C O'CallaghanA Swarbrick
Aug 1, 1974·Archives of Disease in Childhood·M Radford
Jan 1, 1984·Archives of Disease in Childhood·R L HenryG M Stokes
Jan 1, 1982·Respiration; International Review of Thoracic Diseases·C Geller-Bernstein, S Levin

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Citations

Apr 1, 1997·Thorax·P W Barry, C O'Callaghan
Jan 1, 1996·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·J C de Jongste

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