Nebulization of Poractant alfa via a vibrating membrane nebulizer in spontaneously breathing preterm lambs with binasal continuous positive pressure ventilation

Pediatric Research
Matthias HüttenBoris W Kramer

Abstract

Surfactant replacement therapy is the gold standard treatment of neonatal respiratory distress (RDS). Nebulization is a noninvasive mode of surfactant administration. We administered Poractant alfa (Curosurf) via a vibrating perforated membrane nebulizer (eFlow Neonatal Nebulizer) to spontaneously breathing preterm lambs during binasal continuous positive pressure ventilation (CPAP). Sixteen preterm lambs were operatively delivered at a gestational age of 133 ± 1 d (term ~150 d), and connected to CPAP applied via customized nasal prongs. Nebulization was performed (i) with saline or (ii) with surfactant for 3 h in humidified or (iii) nonhumidified air, and with surfactant (iv) for 60 min or (v) for 30 min. We measured arterial oxygenation, lung gas volumes and surfactant pool size and deposition. Nebulization of surfactant in humidified air for 3 h improved oxygenation and lung function, and surfactant was preferentially distributed to the lower lung lobes. Shorter nebulization times and 3 h nebulization in dry air did not show these effects. Nebulized surfactant reached all lung lobes, however the increase of surfactant pool size missed statistical significance. Positive effects of surfactant nebulization to spontaneously brea...Continue Reading

References

Feb 1, 1991·Journal of Applied Physiology·J F LewisB Tabor
Jun 1, 1984·Critical Care Medicine·T A MarshallT L Austin
May 5, 2000·The Cochrane Database of Systematic Reviews·R F Soll, C J Morley
Aug 2, 2000·Critical Care Medicine·M H WagnerM Obladen
Nov 9, 2000·American Journal of Respiratory and Critical Care Medicine·A H JobeM Ikegami
Jun 19, 2001·The Cochrane Database of Systematic Reviews·R F Soll, C J Morley
Oct 27, 2004·American Journal of Respiratory and Critical Care Medicine·Neil MulrooneyAlan H Jobe
Jul 21, 2006·The Cochrane Database of Systematic Reviews·D Roberts, S Dalziel
Nov 6, 2007·American Journal of Obstetrics and Gynecology·Alan H JobeJohn P Newnham
Apr 17, 2009·The Cochrane Database of Systematic Reviews·Nadine Seger, Roger Soll
May 7, 2009·Journal of Perinatology : Official Journal of the California Perinatal Association·J Wirbelauer, C P Speer
Oct 15, 2009·International Journal of Pharmaceutics·A Arzhavitina, H Steckel
May 12, 2010·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Neil N FinerRobert Segal
Oct 26, 2010·Archives of Disease in Childhood. Fetal and Neonatal Edition·Peter A DargavilleAntonio G De Paoli
Jan 14, 2011·Neonatology·Anton H van KaamUNKNOWN Neovent Study Group
Jul 9, 2011·Journal of Perinatology : Official Journal of the California Perinatal Association·A TarawnehG M Sant'anna
Sep 3, 2011·Journal of Perinatology : Official Journal of the California Perinatal Association·R RamanathanF R Ernst
Aug 3, 2012·The European Respiratory Journal·J Jane Pillow
Sep 4, 2012·Neonatology·J Jane Pillow, S Minocchieri
Oct 29, 2013·American Journal of Physiology. Lung Cellular and Molecular Physiology·Markus FehrholzSteffen Kunzmann
Jun 12, 2014·PeerJ·Frans J WaltherAlan J Waring

❮ Previous
Next ❯

Citations

Jul 26, 2017·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Ilaria MilesiRaffaele L Dellaca'
Mar 21, 2020·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Carmen Rey-SantanoBegoña Loureiro
Feb 6, 2019·Aerosol Science and Technology : the Journal of the American Association for Aerosol Research·Xin Heng, Donovan B Yeates
Jan 12, 2020·Pediatric Research·Roland HentschelOlivier Danhaive
Feb 28, 2021·Respiratory Research·Federico BiancoJane Pillow
May 8, 2021·Pediatric Pulmonology·Carmen Rey-SantanoMiguel Angel Gomez-Solaetxe

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.