Nebulized amphotericin B combined with intravenous amphotericin B in rats with severe invasive pulmonary aspergillosis.

Antimicrobial Agents and Chemotherapy
Elisabeth J RuijgrokArnold G Vulto

Abstract

Nebulized amphotericin B (AMB) combined with intravenous AMB was studied in persistently leukopenic rats with invasive pulmonary aspergillosis. Pulmonary concentrations of AMB after aerosol treatment were substantially higher than after intravenous liposomal AMB. Nebulized liposomal AMB in addition to intravenous AMB resulted in significantly prolonged survival compared to controls.

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Citations

May 27, 2010·Current Fungal Infection Reports·Jennifer Le, Daryl S Schiller
Sep 20, 2007·Expert Opinion on Drug Safety·Stephanie A Knechtel, Michael E Klepser
Jan 16, 2008·Transplant Infectious Disease : an Official Journal of the Transplantation Society·K M HoR Murray
May 27, 2010·Pharmacotherapy·Jennifer LeUNKNOWN Society of Infectious Diseases Pharmacists Aerosolized Antimicrobials Task Force
Jun 1, 2017·Frontiers in Microbiology·Guillaume Desoubeaux, Carolyn Cray

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