Nebulized heparin for inhalation injury in burn patients: a systematic review and meta-analysis

Burns and Trauma
Xiaodong LanYuesheng Huang

Abstract

Smoke inhalation injury increases overall burn mortality. Locally applied heparin attenuates lung injury in burn animal models of smoke inhalation. It is uncertain whether local treatment of heparin is benefit for burn patients with inhalation trauma. We systematically reviewed published clinical trial data to evaluate the effectiveness of nebulized heparin in treating burn patients with inhalation injury. A systematic search was undertaken in PubMed, the Cochrane Library, Embase, Web of Science, the Chinese Journals Full-text Database, the China Biomedical Literature Database and the Wanfang Database to obtain clinical controlled trails evaluating nebulized heparin in the treatment of burn patients with inhalation injury. Patient and clinical characteristics, interventions and physiological and clinical outcomes were recorded. Cochrane Risk of Bias Evaluation Tool and the Newcastle-Ottawa Scale were used to evaluate data quality. Potential publication bias was assessed by Egger's test. A sensitivity analysis was conducted to assess the stability of the results. The meta-analysis was conducted in R 3.5.1 software. Nine trials were eligible for the systematic review and meta-analysis. Nebulized heparin can reduce lung injury and...Continue Reading

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Citations

May 19, 2021·Burns : Journal of the International Society for Burn Injuries·O C NduagubamS Agwu
Jun 6, 2021·Journal of Burn Care & Research : Official Publication of the American Burn Association·John W KeylounUNKNOWN SYSCOT Study Group
Jan 13, 2022·Journal of Burn Care & Research : Official Publication of the American Burn Association·Wei ZhuHuapei Song

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Software Mentioned

Cochrane Risk of Bias Evaluation Tool
Cochrane System Evaluator

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