Nebulized hypertonic saline treatment in hospitalized children with moderate to severe viral bronchiolitis

Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases
Zhengxiu LuoXiqiang Yang

Abstract

The objective of this study was to determine the efficacy and safety of frequently inhaled nebulized hypertonic saline (HS) in infants with moderate to severe bronchiolitis. One hundred and twenty-six infants were randomized to receive either nebulized 3% hypertonic saline (HS) or 0.9% normal saline (NS), but only 112 patients completed the whole study. Cough, wheezing, pulmonary physical signs, clinical severity scores and the hospital length of stay (LOS) were recorded. The wheezing remission time was 4.8 ± 1.0 days in the NS group and 3.6 ± 0.9 days in the HS group (p <0.01). The cough remission time was 5.5 ± 0.9 days in the NS group and 4.3 ± 0.7 days in the HS group (p <0.01). The moist crackles disappeared at 6.2 ± 0.7 days in the NS group and at 4.4 ± 0.9 days in the HS group (p <0.01). The clinical severity scores decreased more significantly in the HS group than in the NS group on each day within 96 h after enrolment (p <0.01). The LOS decreased from 6.4 ± 1.4 days in the NS group to 4.8 ± 1.2 days in the HS group (p <0.01). The treatment was well tolerated, with no adverse effects attributable to nebulized HS. The conclusions are that frequently inhaled HS relieved symptoms and signs faster than NS, and shortened LOS...Continue Reading

References

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Citations

Jan 25, 2012·Journal of Ophthalmology·Abbott L Willard, Ira M Herman
Mar 22, 2016·The Journal of Pediatric Pharmacology and Therapeutics : JPPT : the Official Journal of PPAG·Jeffrey Baron, Gladys El-Chaar
Nov 13, 2014·Thorax·Steve Cunningham, Stefan Achim Unger
Nov 26, 2015·BMC Pulmonary Medicine·Chin MaguireMark L Everard
Mar 10, 2015·The Journal of Pediatrics·Todd A FlorinSamir S Shah
Feb 25, 2018·World Journal of Pediatrics : WJP·Paula HeikkiläMatti Korppi
Jun 28, 2014·The European Respiratory Journal·Jasmijn TeunissenBettina F Loza
Oct 2, 2014·The European Respiratory Journal·Jürg Barben, Claudia E Kuehni
Jul 1, 2014·JAAPA : Official Journal of the American Academy of Physician Assistants·Wendy B Canty, Dawn Colomb-Lippa
Dec 22, 2017·The Cochrane Database of Systematic Reviews·Linjie ZhangTerry P Klassen
Aug 7, 2019·Experimental and Therapeutic Medicine·Zhi-Yong WangXue-Qin Fu
Dec 22, 2017·Pediatric Pulmonology·Paula HeikkiläMatti Korppi
Aug 1, 2013·The Cochrane Database of Systematic Reviews·Linjie ZhangTerry P Klassen
Jul 26, 2017·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Zahra EzzeldinMohamed A Mohamed
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Jan 13, 2018·Pediatric Pulmonology·Yoshihiko MorikawaUNKNOWN Tokyo Pediatric Clinical Research Network

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