Nebulized isotonic saline improves voice production in Sjögren's syndrome

The Laryngoscope
Kristine TannerNelson Roy

Abstract

This study examined the effects of a topical vocal fold hydration treatment on voice production over time. Prospective, longitudinal, within-subjects A (baseline), B (treatment), A (withdrawal/reversal), B (treatment) experimental design. Eight individuals with primary Sjögren's syndrome (SS), an autoimmune disease causing laryngeal dryness, completed an 8-week A-B-A-B experiment. Participants performed twice-daily audio recordings of connected speech and sustained vowels and then rated vocal effort, mouth dryness, and throat dryness. Two-week treatment phases introduced twice-daily 9-mL doses of nebulized isotonic saline (0.9% Na(+) Cl(-) ). Voice handicap and patient-based measures of SS disease severity were collected before and after each 2-week phase. Connected speech and sustained vowels were analyzed using the Cepstral Spectral Index of Dysphonia (CSID). Acoustic and patient-based ratings during each baseline and treatment phase were analyzed and compared. Baseline CSID and patient-based ratings were in the mild-to-moderate range. CSID measures of voice severity improved by approximately 20% with nebulized saline treatment and worsened during treatment withdrawal. Posttreatment CSID values fell within the normal-to-mild ...Continue Reading

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Citations

Dec 5, 2015·Logopedics, Phoniatrics, Vocology·Ziya SaltürkYavuz Uyar
Jan 15, 2019·The Annals of Otology, Rhinology, and Laryngology·Kristine TannerMarshall E Smith
Jan 27, 2017·Journal of Speech, Language, and Hearing Research : JSLHR·Mary J SandageAudrey G Smith
Dec 24, 2018·The Annals of Otology, Rhinology, and Laryngology·Nelson RoyKrishna M Sundar
Feb 10, 2021·Journal of Speech, Language, and Hearing Research : JSLHR·Jenny L PierceNelson Roy
Feb 2, 2021·Journal of Voice : Official Journal of the Voice Foundation·Osnat Grinstein-KorenOfer Amir
Jun 23, 2021·Journal of Voice : Official Journal of the Voice Foundation·Anumitha VenkatramanM Preeti Sivasankar
Jul 17, 2021·Journal of Speech, Language, and Hearing Research : JSLHR·Jenny L PierceNelson Roy
Feb 13, 2020·Journal of Voice : Official Journal of the Voice Foundation·Rouxjeanne VermeulenMarien Alet Graham
May 12, 2020·Journal of Voice : Official Journal of the Voice Foundation·Moa Millgård, Lisa Tuomi

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