Nebulized phosphodiesterase III inhibitor during warm ischemia attenuates pulmonary ischemia-reperfusion injury

The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
Jitian ZhangHiroshi Date

Abstract

The control of warm ischemia-reperfusion injury is crucial in managing donors after cardiac death for lung transplantation. We focused on transalveolar administration as a drug-delivery route for such donors. Milrinone is a phosphodiesterase 3 inhibitor that inhibits the breakdown of cyclic adenosine monophosphate and selectively relaxes smooth muscle. We hypothesized that nebulized milrinone would mitigate warm ischemia-reperfusion injury of lung. This study was conducted with an isolated rat lung perfusion model. Lungs were excised, exposed to 55-minute ischemia at 37 degrees C, and reperfused for 60 minutes. During ischemia, nebulized milrinone (n = 6) or saline (n = 6) was inhaled. Lungs were continuously perfused without ischemia as a sham group (n = 6). Airway resistance, pulmonary vascular resistance, pulmonary compliance, weight gain and blood gas were measured. Adenine nucleotide levels and apoptosis were investigated in the reperfused lungs. Milrinone nebulization decreased post-ischemic pulmonary vascular resistance (0.98 +/- 0.05 and 1.74 +/- 0.17 cm H(2)O/ml.min at 60 minutes of reperfusion in the milrinone and control groups, respectively [p < 0.01]). It did not alter cyclic adenosine monophosphate levels, but it ...Continue Reading

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Citations

Aug 28, 2012·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Akihiro OhsumiHiroshi Date
Jul 24, 2012·Transplant International : Official Journal of the European Society for Organ Transplantation·Akihiro OhsumiHiroshi Date
Jun 23, 2011·Transplantation Proceedings·T NishikiM Tanaka
Dec 3, 2014·Journal of Cardiothoracic and Vascular Anesthesia·Maxime LaflammeAndré Y Denault
Apr 8, 2019·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Seyit Mehmet CeylanMustafa Emre Gulbagci
Jul 1, 2020·Annals of Vascular Surgery·Esin AkSule Çetinel

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