Necessary, but Not Sufficient. The Benefit Concept in the Project Evaluation of Animal Research in the Context of Directive 2010/63/EU

Animals : an Open Access Journal From MDPI
Matthias Eggel, Herwig Grimm

Abstract

Directive 2010/63/EU (henceforth "Directive") on the protection of animals used for scientific purposes mandates that every project proposal in EU member states involving procedures on living non-human vertebrates and cephalopods has to be approved in an review process, including a harm-benefit-analysis (HBA), to assess "whether the harm to the animals in terms of suffering, pain and distress is justified by the expected outcome taking into account ethical consideration and may ultimately benefit human beings, animals or the environment". Despite the justifying relevance of "outcome" and "benefit", it remains unclear how to understand these concepts. However, national authorities and applicants require a clear understanding of this to carry out a HBA. To analyze the underlying premises of the HBA and its consequences for the evaluation process, we introduce a heuristic to analyze the relation between "outcome", "benefit" and "prospective benefit assessment". We then apply the heuristic to all seven legitimate purposes for animal research stated in the Directive, namely basic research, translational or applied research, product safety, education and training, protection of the environment, preservation of species and forensic in...Continue Reading

References

Mar 12, 1992·Nature·D G Porter
Nov 1, 1974·Circulation Research·J H Comroe, R D Dripps
Aug 13, 1999·The American Journal of Gastroenterology·E B HunterJ A Awad
Feb 21, 2006·British Journal of Clinical Pharmacology·J K Aronson
Jul 27, 2007·Journal of the National Cancer Institute·John Dudley Miller
Nov 1, 2007·European Journal of Immunology·Warner C Greene
Jan 10, 2008·JAMA : the Journal of the American Medical Association·Steven H Woolf
Nov 6, 2008·Nature·Quirin Schiermeier
May 1, 2008·Journal of Diabetes Science and Technology·Lutz Heinemann
Feb 26, 2010·Academic Medicine : Journal of the Association of American Medical Colleges·Doris McGartland RubioKarin Esposito
Dec 15, 2010·Nature·Alison Abbott
May 17, 2011·Pharmacoepidemiology and Drug Safety·Zaina P QureshiSheryl L Szeinbach
Sep 1, 2011·Diabetes Research and Clinical Practice·Dimitrios T Karamitsos
Mar 31, 2012·Nature·C Glenn Begley, Lee M Ellis
Jun 1, 2004·Alternatives to Laboratory Animals : ATLA·David J Mellor
Nov 20, 2013·Nature Reviews. Neurology·David W HowellsMalcolm R Macleod
Jul 30, 2014·Alternatives to Laboratory Animals : ATLA·Jarrod BaileyMichael Balls
Oct 22, 2014·Lab Animal·Henriëtte J BoutEdgar D Karssing
Apr 1, 2015·Future Microbiology·Ananda S BandyopadhyayWalter A Orenstein
Sep 26, 2015·Cell·R Sanders WilliamsAlexander R Pico
Jun 10, 2017·Alternatives to Laboratory Animals : ATLA·Herwig Grimm, Matthias Eggel
Aug 5, 2017·Laboratory Animals·Adrian J SmithTrond Brattelid

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Citations

Apr 12, 2019·Animals : an Open Access Journal From MDPI·Katrien Devolder, Matthias Eggel
Dec 21, 2019·Cambridge Quarterly of Healthcare Ethics : CQ : the International Journal of Healthcare Ethics Committees·Matthias EggelHerwig Grimm
May 21, 2020·Animals : an Open Access Journal From MDPI·Anne ZintzschHerwig Grimm
Dec 7, 2018·Neonatology·Jane Marie AlsweilerJane Elizabeth Harding

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