Abstract
A minimum of 15 lymph nodes (LNs) has been recommended as an adequate number for radical gastrectomy for gastric cancer (GC). This study aimed to investigate whether the harvesting of at least 25 LNs was a better criterion for stage N2-3 GC based on the 10-year experience of a high-volume hospital. A total of 1363 patients who underwent radical gastrectomy for gastric cancer between 2000 and 2010 were included in this study. The relationship between the number of lymph nodes examined during gastrectomy and overall survival (OS) was analyzed. In multivariate analysis, the numbers of LNs examined (P = 0.001) and N stage were confirmed as 2 of the independent prognostic factors. A larger proportion of N2/N3a/N3b patients was observed in the group with ≥20 LNs examined. The cutoff of ≥25 LNs examined exhibited a significantly lower hazard ratio (HR) than other LN cutoffs among N2-N3 diseases, but the cutoff was not significantly superior to other cutoffs in patients with N0 and N1 disease (HR, 0.64, 0.62, and 0.53 for N2, N3a, and N3b, respectively). The 5-year OS rates were 58.59% and 32.77% for N2 and N3 diseases, respectively, with ≥25 LNs examined, which represents a significant improvement over 15-24 LNs examined (52.48% and 2...Continue Reading
References
Oct 28, 1998·Annals of Surgery·J R SiewertJ D Roder
Apr 3, 1999·British Journal of Cancer·A CuschieriP Fayers
Jul 16, 2005·Radiology·Hye Jin KimHyun Kwon Ha
Sep 30, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·David D SmithRoderich E Schwarz
Nov 10, 2006·Annals of Surgical Oncology·Roderich E Schwarz, David D Smith
Jan 27, 2007·Radiology·Chiao-Yun ChenGin-Chung Liu
Apr 17, 2007·Annals of Surgery·Peter C EnzingerCharles S Fuchs
Mar 13, 2009·Surgery Today·Jian-Kun HuJia-Ping Chen
Feb 4, 2010·Journal of the American College of Surgeons·Xin-Zu ChenJia-Ping Chen
Apr 23, 2010·The Lancet Oncology·Ilfet SongunCornelis J H van de Velde
Jun 22, 2010·Annals of Surgery·Gian Luca BaiocchiGiovanni De Manzoni
Feb 4, 2011·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·R BiffiB Andreoni
Mar 12, 2011·Annals of Surgery·Muhammed Ashraf MemonBreda Memon
May 17, 2011·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·UNKNOWN Japanese Gastric Cancer Association
May 17, 2011·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·UNKNOWN Japanese Gastric Cancer Association
Nov 2, 2011·Annals of Surgery·Xin-Zu ChenCheng Zhou
Mar 29, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S HirabayashiK Akazawa
Aug 7, 2014·European Radiology·Takuro SaitoYuichiro Doki
Citations
Dec 9, 2015·World Journal of Surgical Oncology·Wei-Han ZhangJian-Kun Hu
Sep 14, 2016·Annals of Surgical Oncology·Jun LuZhi-Wei Zhou
Nov 11, 2016·Annals of Surgical Oncology·Gaozan ZhengHongwei Zhang
Mar 28, 2019·JAMA Surgery·Wei-Wei WuTao Zhu
Oct 30, 2016·The Oncologist·Yu-Yin LiuTa-Sen Yeh
Oct 27, 2015·Medicine·Hai-Ning ChenJian-Kun Hu
Mar 31, 2016·Oncotarget·Xin-Zu ChenJian-Kun Hu
Jul 7, 2018·Medicine·Yinghao CaoKailin Cai
Nov 7, 2019·Journal of Gastrointestinal Cancer·Stefano RauseiRiccardo Rosati
May 10, 2017·BioMed Research International·Rong LiCan-Xia Xu
Oct 9, 2020·Surgical Endoscopy·Hua YangJian-Kun Hu
Dec 25, 2015·Cancer Research·Hai-Ning ChenCanhua Huang