Necessity of meningococcal gamma-glutamyl aminopeptidase for Neisseria meningitidis growth in rat cerebrospinal fluid (CSF) and CSF-like medium

Journal of Bacteriology
Hideyuki TakahashiHaruo Watanabe

Abstract

The growth of a gamma-glutamyl aminopeptidase (GGT)-deficient Neisseria meningitidis strain was much slower than that of the parent strain in rat cerebrospinal fluid (CSF) and in a synthetic CSF-mimicking medium, and the growth failure was suppressed by the addition of cysteine. These results suggested that, in the environment of cysteine shortage, meningococcal GGT provided an advantage for meningococcal multiplication by supplying cysteine from environmental gamma-glutamyl-cysteinyl peptides.

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Citations

Jul 25, 2009·Nihon saikingaku zasshi. Japanese journal of bacteriology·Hideyuki Takahashi
Oct 6, 2005·Journal of Biochemistry and Molecular Biology·Hyun-Jung KangChang-Jin Lim
Apr 11, 2014·TheScientificWorldJournal·Sharath Balakrishna, Asmita Prabhune
Nov 11, 2008·Cell Host & Microbe·Dirk HofreuterJorge E Galán
Jul 16, 2014·Expert Review of Proteomics·Myron Christodoulides

Related Concepts

AB089320
Metazoa
Cerebrospinal Fluid
Cysteine Hydrochloride
Gamma-glutamyl transferase
Neisseria meningitidis
Rats, Laboratory

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