Neck duplex Doppler ultrasound evaluation for assessing chronic cerebrospinal venous insufficiency in multiple sclerosis patients

Phlebology
Maciej ZaniewskiK Pawlicki

Abstract

Recent clinical studies have suggested a relationship between multiple sclerosis (MS) and the occurrence of pathological changes in the jugular, vertebral and azygous veins that result in abnormal blood outflow from the brain and the spinal cord. Together, these pathological changes have been designated chronic cerebrospinal venous insufficiency (CCSVI). The aim of the present study was to evaluate the usefulness of duplex Doppler ultrasound in the evaluation of central nervous system venous outflow disturbances in patients suffering from MS. We examined 181 patients with MS, diagnosed on the basis of the McDonald criteria, and 50 healthy volunteer controls. All patients underwent Doppler ultrasound examination of the internal jugular veins (IJV) and vertebral veins (VVs). The presence of outflow disturbances and morphological abnormalities were evaluated. Pathological changes in the extracranial jugular veins were diagnosed in 148/181 MS patients (82%) and 7/50 control group volunteers (14%). The following abnormalities in the MS group were revealed: the presence of a reflux in the IJVs and/or VVs (54%), narrowing (54%), a complete block in the flow through the IJV (10%) and an abnormal postural control of the cerebral outflow...Continue Reading

References

Jul 9, 2002·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Nabil Maalikjy AkkawiAlessandro Padovani
Jul 31, 2004·The Journal of Physiology·J GisolfJ M Karemaker
Nov 12, 2005·Annals of Neurology·Chris H PolmanJerry S Wolinsky
Mar 3, 2006·The New England Journal of Medicine·Elliot M FrohmanCedric S Raine
May 17, 2006·Current Opinion in Neurology·Michael H Barnett, Ian Sutton
Jul 13, 2006·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M PugliattiI Milanov
Nov 30, 2007·Current Neurovascular Research·Paolo ZamboniFabrizio Salvi
Nov 11, 2008·Current Neurovascular Research·Erica Menegatti, Paolo Zamboni
Dec 9, 2008·Journal of Neurology, Neurosurgery, and Psychiatry·P ZamboniF Salvi
Jan 16, 2009·Journal of the Neurological Sciences·Paolo ZamboniFabrizio Salvi
Jun 19, 2009·Current Neurovascular Research·Paolo ZamboniFrancesco Carinci
Sep 3, 2009·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Ajay Vikram Singh, Paolo Zamboni
Dec 5, 2009·Journal of Vascular Surgery·Paolo ZamboniFabrizio Salvi

❮ Previous
Next ❯

Citations

Jan 25, 2013·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Giancarlo ComiGianluigi Mancardi
Mar 4, 2014·Therapeutic Advances in Neurological Disorders·Georgios TsivgoulisChristos Krogias
Sep 10, 2013·Multiple Sclerosis : Clinical and Laboratory Research·G ComiUNKNOWN CoSMo Collaborative Study Group
Jul 24, 2013·BMC Neurology·Chun-Yu ChengHan-Hwa Hu
Apr 25, 2018·CNS Neuroscience & Therapeutics·Da ZhouRan Meng

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.