Necklace-Like Microfibers with Variable Knots and Perfusable Channels Fabricated by an Oil-Free Microfluidic Spinning Process

Advanced Materials
Ruoxiao XieQionglin Liang

Abstract

Fiber materials with different structural features, which in many cases endow the fibers extraordinary functions, are drawing considerable attention from biomedical and material researchers. Here, perfusable necklace-like knotted microfibers are presented for the first time. Additionally, a novel microfluidic spinning method facilitates the production of variable knots and channels. Not only spindle-, but also hemisphere- and petal-knotted microfibers can be controllably fabricated. Generation and perfusion of both Janus channels and helical channel in the knotted microfibers are also shown. With no need of oil and surfactant, the spinning process is highly cytocompatible. The potential bioengineering and biomedical application of the knotted hollow microfiber is demonstrated by its cell-encapsulation feasibility and the unique liver acinus-like diffusion gradient in the knot. The merits of perfusability, cytocompatibility, and structural diversity of the microfibers may open more avenues for further material and biomedical investigation.

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Citations

Oct 23, 2018·Advanced Materials·Ruihua DongXingyu Jiang
Aug 15, 2020·Frontiers in Bioengineering and Biotechnology·Chizhu DingXianghua Yan
Apr 16, 2020·Advanced Biosystems·Jie WangYuanjin Zhao
Jan 16, 2021·Langmuir : the ACS Journal of Surfaces and Colloids·Wei GaoYongping Chen
Apr 17, 2021·Journal of Hazardous Materials·Jialiang XiongQionglin Liang
May 8, 2021·ACS Applied Materials & Interfaces·Sara Seidelin MajidiMenglin Chen
Jun 2, 2020·ACS Applied Materials & Interfaces·Yufang LiuYongmei Zheng
Feb 16, 2019·ACS Nano·Luoran ShangYuanjin Zhao
Mar 18, 2020·ACS Applied Materials & Interfaces·Yunru YuYuanjin Zhao
Mar 7, 2020·Langmuir : the ACS Journal of Surfaces and Colloids·Yoshiko TakenakaIgor Musevic
Nov 5, 2020·ACS Applied Materials & Interfaces·Jialiang XiongQionglin Liang
Nov 27, 2021·Small·Chaoyu YangYuanjin Zhao

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