Necrobiosis lipoidica associated with sarcoidosis

Journal of Cutaneous Pathology
Jack LeeMary-Margaret B Noland

Abstract

We report the case of a 40-year-old African-American female with biopsy-proven pulmonary sarcoidosis who developed atrophic plaques on her shins, trunk, and scalp that were clinically and histologically consistent with necrobiosis lipoidica (NL). The lesions appeared 3 years after her diagnosis of sarcoidosis, and progressed despite chronic prednisone. Sarcoidosis and NL are granulomatous skin disorders reported to coexist in the same patient only 10 times in the literature. Including the current case, patients have been exclusively females around middle age, and have greater tendencies to develop typical cutaneous sarcoidosis. The incidence of diabetes is rare in this group. Like typical NL, NL associated with sarcoidosis tends to ulcerate, and is difficult to treat. Interestingly, there are six similar cases reported in the literature of patients with sarcoidosis who developed lesions clinically and behaviorally consistent with NL, but received a final histological diagnosis of sarcoidosis. These cases share very similar demographics and clinical features with cases of true NL associated with sarcoidosis, and often have more ambiguous histology containing features of both cutaneous sarcoidosis and NL. Comparing the two sets o...Continue Reading

References

Jul 1, 1991·Clinical and Experimental Dermatology·K GudmundsenF C Powell
Jul 1, 1987·Clinical and Experimental Dermatology·B E Monk, A W Du Vivier
May 1, 1985·Clinical and Experimental Dermatology·R A Graham-BrownI Sarkany
Jan 1, 1984·Archives of Dermatology·N SaxeW Gordon
Nov 27, 1998·The Journal of Dermatology·K IgawaK Nishioka
Dec 6, 2001·American Journal of Respiratory and Critical Care Medicine·R P BaughmanUNKNOWN Case Control Etiologic Study of Sarcoidosis (ACCESS) research group
Dec 20, 2007·Joint, Bone, Spine : Revue Du Rhumatisme·Vinia MendozaSandra Weibel
Oct 31, 2014·The American Journal of Dermatopathology·Joshua M Schulman, Philip E LeBoit

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Citations

Jul 18, 2019·The American Journal of Dermatopathology·Neha ChandanMarylee Braniecki
Nov 14, 2019·Nigerian Journal of Clinical Practice·H Yahya
Dec 29, 2020·Health Science Reports·Ingrid CamposGilles Landman
May 8, 2021·International Journal of Dermatology·Galal El EnanyMona R E Abdel-Halim
Apr 23, 2021·Actas dermo-sifiliográficas·J Aróstegui AguilarA Fernandez-Flores
Aug 26, 2021·Indian Dermatology Online Journal·Debajyoti ChatterjeeUma Nahar Saikia

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