Necrobiotic xanthogranuloma associated with paraproteinemia and non-Hodgkin's lymphoma developing into chronic lymphocytic leukemia: the first case reported in the literature and review of the literature

International Journal of Dermatology
Oumeish Youssef OumeishAsem Sharaiha

Abstract

A 56-year-old married female presented in May 1998 with a 5-month history of xanthelasma of the eyelids, followed 4 months later by two enlarged lymph nodes of the left side of the neck and three of the left axilla. At the same time, she developed xanthomatous patches on the face, neck, and shoulders (Fig. 1). The cutaneous lesions were xanthomatous nodules and plaques, affecting the periorbital regions. Later, the whole face was affected, followed by ulcerated lesions on the scalp, chest, back, and extremities (Fig. 2). The skin lesions became painful, pruritic, ulcerated tumors (Fig. 3). In July 1998, computed tomography (CT) scans of the chest and abdomen with contrast medium showed pretracheal, bilateral axillary, right retrochural, paracaval, aortocaval, and para-aortic lymph node enlargement. These findings were suggestive of lymphoma. CT scan also showed slight heterogeneous hypodensity in the upper part of the right lobe of the liver, suggesting fatty infiltration. The spleen, pancreas, and suprarenal glands appeared normal. One cervical and two left axillary lymph nodes were excised. They revealed total replacement of the nodular architecture by a diffuse proliferation of mature lymphoid cells having small nuclei and a...Continue Reading

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Citations

Jul 13, 2011·Dermatology Research and Practice·Siriluk InthasottiJane Manonukul
Feb 24, 2016·Clinics in Dermatology·Karolyn A WanatMisha Rosenbach
Jan 20, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Yevgeniy BalagulaMario E Lacouture
Feb 28, 2018·International Journal of Dermatology·Christine FinkFerdinand Toberer
Jul 21, 2016·Journal of the European Academy of Dermatology and Venereology : JEADV·D MiguelP Elsner
Mar 4, 2008·Journal of Cutaneous Pathology·Joan Guitart, Pedram Gerami
Jan 8, 2009·International Journal of Dermatology·Kerith E Spicknall, David A Mehregan
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Jun 5, 2007·Seminars in Cutaneous Medicine and Surgery·Jesús Fernández-Herrera, Javier Pedraz
Nov 26, 2009·The Medical Clinics of North America·Ravi Ubriani, Marc E Grossman

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