Necrobiotic xanthogranuloma associated with smoldering multiple myeloma: satisfactory response to cyclophosphamide, dexamethasone, and thalidomide.

Anais Brasileiros De Dermatologia
Renan Bernardes de Mello, Everton Carlos Siviero do Vale

Abstract

Necrobiotic xanthogranuloma is a rare chronic condition, belonging to the group C non-Langerhans cell histiocytoses, which is relevant due to the possibility of extracutaneous involvement and association with systemic diseases, particularly hematologic malignancies. The case reported here was only diagnosed after nine years of evolution and was associated with plasma cell dyscrasia. After treatment with cyclophosphamide, dexamethasone, and thalidomide, there was a reduction of cutaneous lesions and serum levels of monoclonal protein.

References

Jun 5, 2007·Seminars in Cutaneous Medicine and Surgery·Jesús Fernández-Herrera, Javier Pedraz
Jan 8, 2009·International Journal of Dermatology·Kerith E Spicknall, David A Mehregan
Mar 12, 2016·Blood·Jean-François EmileUNKNOWN Histiocyte Society
May 31, 2016·Clinical Lymphoma, Myeloma & Leukemia·Larissa S HigginsWilson I Gonsalves
Jul 21, 2016·Journal of the European Academy of Dermatology and Venereology : JEADV·D MiguelP Elsner
May 14, 2017·International Journal of Dermatology·Can BaykalNesimi Buyukbabani
Oct 20, 2017·Clinical and Experimental Dermatology·P MahendranJ Natkunarajah
Mar 24, 2018·Annals of Hematology·Talal HilalCraig B Reeder

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Methods Mentioned

BETA
ESR
biopsy
surgical resection

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