Necroptosis: a crucial pathogenic mediator of human disease

JCI Insight
Mary E ChoiAugustine M K Choi

Abstract

Necroptosis is a genetically regulated form of necrotic cell death that has emerged as an important pathway in human disease. The necroptosis pathway is induced by a variety of signals, including death receptor ligands, and regulated by receptor-interacting protein kinases 1 and 3 (RIPK1 and RIPK3) and mixed-lineage kinase domain-like pseudokinase (MLKL), which form a regulatory necrosome complex. RIPK3-mediated phosphorylation of MLKL executes necroptosis. Recent studies, using animal models of tissue injury, have revealed that RIPK3 and MLKL are key effectors of injury propagation. This Review explores the functional roles of RIPK3 and MLKL as crucial pathogenic determinants and markers of disease progression and severity in experimental models of human disease, including acute and chronic pulmonary diseases; renal, hepatic, cardiovascular, and neurodegenerative diseases; cancer; and critical illness.

References

Apr 29, 1998·Annual Review of Physiology·G KroemerM Resche-Rigon
Jun 8, 1999·The Journal of Biological Chemistry·X SunV M Dixit
Oct 30, 2003·The European Respiratory Journal·P J BarnesR A Pauwels
Jan 13, 2006·Nature Chemical Biology·Alexei DegterevJunying Yuan
Nov 3, 2006·American Journal of Respiratory Cell and Molecular Biology·Dirk-Jan SlebosAugustine M K Choi
Apr 14, 2007·Cell Death and Differentiation·L GalluzziG Kroemer
Apr 15, 2008·Nature Chemical Biology·Alexei DegterevJunying Yuan
Mar 23, 2010·Cell·Kate Schroder, Jurg Tschopp
Oct 20, 2010·Proceedings of the National Academy of Sciences of the United States of America·Zhi-Hua ChenAugustine M K Choi
Mar 4, 2011·Nature·William J KaiserEdward S Mocarski
Nov 13, 2012·Annual Review of Physiology·Judith Campisi
Dec 25, 2012·Immunity·Tae-Bong KangDavid Wallach
Jul 10, 2013·Cell Research·Jianfeng WuJiahuai Han
Sep 10, 2013·Immunity·James M MurphyWarren S Alexander
Sep 11, 2013·The Journal of Biological Chemistry·William J KaiserEdward S Mocarski
Oct 10, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A LauA M Jevnikar
Nov 26, 2013·Cell Reports·Stephen W G TaitDouglas R Green
Jan 21, 2014·Nature Medicine·Einat B VitnerAnthony H Futerman
Jan 31, 2014·The New England Journal of Medicine·Andreas Linkermann, Douglas R Green
May 13, 2014·Cell Reports·Yves DondelingerPeter Vandenabeele

❮ Previous
Next ❯

Citations

Dec 13, 2019·The FEBS Journal·Shrikant R MulayHans-Joachim Anders
Mar 3, 2020·Journal of Cellular and Molecular Medicine·Shengju YangYan Lu
Feb 23, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Bo LiuZamaneh Kassiri
Jun 25, 2020·Circulation. Heart Failure·Peng XiaoXuejun Wang
Jun 26, 2020·Biological & Pharmaceutical Bulletin·Takehiro YamadaKen Iseki
Aug 18, 2020·Cellular and Molecular Life Sciences : CMLS·C Corbin FryeHrishikesh S Kulkarni
Sep 9, 2020·Journal of Leukocyte Biology·Mitchell KlompM Nadeem Khan
Oct 1, 2020·Annals of Medicine·Silvestro Ennio D'AnnaAntonino Di Stefano
Jan 31, 2020·Oxidative Medicine and Cellular Longevity·Yu-Pu HongWei-Xing Wang
Aug 23, 2020·International Journal of Molecular Sciences·Raji BaidyaKim R Bridle
Oct 6, 2020·The Journal of Trauma and Acute Care Surgery·Juan-Pablo IdrovoElizabeth J Kovacs
Mar 11, 2020·Cells·Xuewei ZhangKazuyuki Kitatani
Sep 9, 2020·Annals of the Rheumatic Diseases·Jimin JeonYou-Sun Kim
Oct 8, 2020·Molecular and Cellular Biochemistry·Bhargav N WaghelaChandramani Pathak
Jun 5, 2020·The Biochemical Journal·Zhou ZhouMingui Fu
Jan 20, 2021·Cell Death and Differentiation·Yanxiang MengJames M Murphy
Aug 14, 2020·Current Opinion in Microbiology·Hiroshi AshidaChihiro Sasakawa
Jun 6, 2020·The FEBS Journal·Florens LohrmannPhilipp Henneke
Dec 10, 2020·Biomarker Research·Zhaoqing LiJichun Zhou
Dec 5, 2020·Cell Death and Differentiation·Theresa RiebelingStefan Krautwald
Jan 13, 2021·Neural Regeneration Research·Wei-Tao YanKun Xiong
Jan 31, 2021·Cells·So-Young KimEun Young Lee
Feb 23, 2021·The Journal of Thoracic and Cardiovascular Surgery·Satoshi UedaHiroshi Date
Mar 5, 2021·Toxicology·Gopalapura J VishalakshiKesturu S Girish
Mar 7, 2021·Metabolites·Marcos A Perez, Jennifer L Watts
Mar 27, 2021·Frontiers in Cell and Developmental Biology·Emmanuelle Canet-SoulasDavid Magne
Mar 14, 2021·Apoptosis : an International Journal on Programmed Cell Death·Atsushi MuraoPing Wang
Apr 4, 2021·Journal of Fungi·Thomas J WilliamsDarius Armstrong-James
Sep 26, 2020·Arhiv za higijenu rada i toksikologiju·Ivana ČepelakDaniela Čepelak Dodig
Apr 12, 2021·Mitochondrion·Vivek Kumar SharmaVineet Mehta
May 7, 2021·Cell Death and Differentiation·Sofie MartensNozomi Takahashi
Jun 3, 2021·International Journal of Molecular Sciences·Stefan W Ryter
Jun 3, 2021·Experimental & Molecular Medicine·Jinho SeoJaewhan Song
Jun 12, 2021·Cell Death & Disease·Michittra BoonchanKoji Yasutomo

❮ Previous
Next ❯

Methods Mentioned

BETA
transgenic

Related Concepts

Related Feeds

Biomarkers for Cardiovascular Risk Assessment

Sensitive and accurate biomarkers used in cardiovascular risk prediction can potentially be used to manage the risk of cardiovascular disease. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here.