Necroptosis in Acute Kidney Injury

Nephron
Hans-Joachim Anders

Abstract

Regulated necrosis is an expanding research field with important implications for acute kidney injury (AKI). A focused review of the evolving evidence for necroptosis in AKI, one of several forms of regulated necrosis defines the known and unknown. A literature search was performed in PUBMED and ScienceDirect between January 1957 and April 2018 using the following keywords: "acute kidney injury," "necrosis," "necroptosis," "necroinflammation." The necroptosis signaling cascade involves a number of proteins including receptor-interacting protein-1 (RIPK1), RIPK3, and mixed lineage kinase domain-like pseudokinase (MLKL) as well as the MLKL regulator RGMb. The existing experimental evidence in AKI based on mice with genetic deletions of these proteins, more or less specific inhibitory compounds, and diverse experimental AKI models is reviewed. There is broad consistency suggesting a role for necroptosis in AKI, but some studies report divergent evidence potentially relating to the specific model used and the time point of analysis. Mlkl-deficient mice are currently the most specific and reliable experimental tool to study necroptosis in vivo (in kidney disease). The clinical potential of necroptosis inhibition in AKI is to be eval...Continue Reading

References

Jul 3, 2013·Proceedings of the National Academy of Sciences of the United States of America·Andreas LinkermannStefan Krautwald
Jul 9, 2013·Journal of the American Society of Nephrology : JASN·Andreas LinkermannStefan Krautwald
Oct 10, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A LauA M Jevnikar
Oct 18, 2014·Nature Reviews. Immunology·Andreas LinkermannHans-Joachim Anders
Nov 12, 2014·Proceedings of the National Academy of Sciences of the United States of America·Andreas LinkermannStefan Krautwald
Nov 14, 2014·American Journal of Physiology. Renal Physiology·Eduardo HomsiPatricia Janino
Mar 20, 2015·Journal of the American Society of Nephrology : JASN·Yanfang XuJiahuai Han
Sep 4, 2015·Journal of the American Society of Nephrology : JASN·Shrikant R MulayHans-Joachim Anders
Nov 1, 2015·Apoptosis : an International Journal on Programmed Cell Death·Vivian Regina TristãoJúlio Cesar Martins Monte
Nov 5, 2015·European Journal of Immunology·Jyaysi DesaiHans-Joachim Anders
Jan 29, 2016·Nature Communications·Shrikant R MulayHans-Joachim Anders
Jun 25, 2016·Seminars in Nephrology·Jesper KersAndreas Linkermann
Jun 30, 2016·Journal of the American Society of Nephrology : JASN·Diego Martin-SanchezAna B Sanz
Dec 14, 2016·Annual Review of Pathology·Lorenzo GalluzziGuido Kroemer
Jan 12, 2017·Journal of the American Society of Nephrology : JASN·Daigo NakazawaHans-Joachim Anders
Oct 29, 2017·Proceedings of the National Academy of Sciences of the United States of America·Adrian SchreiberRalph Kettritz
Dec 5, 2017·Laboratory Investigation; a Journal of Technical Methods and Pathology·Xiao-Ming MengJun Li
Jan 25, 2018·Cell Death and Differentiation·Lorenzo GalluzziGuido Kroemer
Feb 1, 2018·Proceedings of the National Academy of Sciences of the United States of America·Wenjing LiuYin Xia
Mar 4, 2018·Cell Death & Disease·Anne von MässenhausenAndreas Linkermann
Mar 16, 2018·BMC Nephrology·N R HillR M Tarzi
Mar 29, 2018·Proceedings of the National Academy of Sciences of the United States of America·Diego Martin-SanchezAna Belen Sanz

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Citations

Jun 13, 2019·The Journal of Experimental Medicine·David E Place, Thirumala-Devi Kanneganti
Feb 25, 2020·Circulation Research·Chongxu ShiHans-Joachim Anders
Feb 7, 2021·Nature Reviews. Nephrology·Holger ScholzPontus B Persson
Feb 23, 2021·American Journal of Physiology. Renal Physiology·Fei DengYashpal S Kanwar

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