Necrotic Enteritis in Broiler Chickens: The Role of Tight Junctions and Mucosal Immune Responses in Alleviating the Effect of the Disease

Microorganisms
Nima K EmamiRami A Dalloul

Abstract

Necrotic enteritis (NE) continues to present major challenges to the poultry industry, and the etiologic agent Clostridiumperfringens is the fourth leading cause of bacterially-induced food-&nbsp;borne illnesses in the US. This study was designed to evaluate the effects of a probiotic during naturally occurring NE. On day of hatch, 1080 Cobb 500 male broilers were randomly allocated to three groups (12 replicate pens/treatment, 30 birds/pen) including 1) negative control (NC): corn-soybean meal diet; 2) positive control (PC): NC + 20 mg virginiamycin/kg diet (0.450 kg Stafac®20/ton); and 3) NC + PrimaLac (1.36 and 0.91 kg/ton from 1-21 and 22-42 days, respectively). One day (d) post placement, all birds were challenged by a commercial live oocyst coccidia vaccine as a predisposing factor to NE. Body weight and feed intake were measured at the onset of NE (d 8) and end of each feeding phase. On d 8, small intestines of two birds/pen were examined for NE lesions, and jejunum samples from one bird were collected for mRNA gene expression analysis of tight junction proteins, cytokines, and nutrient transporters. Data were analyzed using the Jump (JMP) software and significance between treatments identified by LSD (P < 0.05). Compare...Continue Reading

References

Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Feb 26, 2004·The American Journal of Pathology·Aisha NazliDerek M McKay
Jul 5, 2006·Nature Clinical Practice. Gastroenterology & Hepatology·R Balfour Sartor
Apr 22, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kevin N CouperEleanor M Riley
Nov 4, 2008·Trends in Microbiology·Filip Van ImmerseelRichard W Titball
Dec 9, 2008·Biochimica Et Biophysica Acta·Julian A Guttman, B Brett Finlay
May 12, 2010·Cold Spring Harbor Perspectives in Biology·Toby Lawrence
May 19, 2010·Developmental Biology·Michelle L BlandMorris J Birnbaum
Mar 25, 2011·The Journal of Nutrition·Dulantha UlluwishewaNicole C Roy
Dec 9, 2015·Avian Pathology : Journal of the W.V.P.A·V TsiourisP Fortomaris
Mar 2, 2016·Avian Pathology : Journal of the W.V.P.A·Robert J Moore
Mar 8, 2016·Avian Pathology : Journal of the W.V.P.A·Gunther AntonissenFilip Van Immerseel
Jun 30, 2016·Nature Reviews. Molecular Cell Biology·Ceniz ZihniMaria S Balda
Nov 20, 2016·Pflügers Archiv : European journal of physiology·Miriam EichnerJörg Piontek
Feb 25, 2017·Cell Death and Differentiation·Xiaofei SunMei-Jun Zhu
Mar 16, 2017·European Journal of Immunology·Kilian EyerichAndrea Cavani
Aug 25, 2017·Open Biology·Xiaofei Sun, Mei-Jun Zhu
Apr 21, 2018·International Journal of Microbiology·Miseon Park, Fatemeh Rafii
May 29, 2018·World's Poultry Science Journal·Meghali Nighot, Prashant Nighot
Feb 6, 2019·Scientific Reports·Tina L MorhardtNobuhiko Kamada
Jan 1, 2018·The Journal of Poultry Science·Kensuke ShimizuTakashi Bungo

❮ Previous
Next ❯