Necrotizing enterocolitis in low birth weight infants in China: Mortality risk factors expressed by birth weight categories

Pediatrics and Neonatology
Tian QianChinese Collaborative Study Group for Neonatal Necrotizing Enterocolitis

Abstract

We retrospectively investigated incidence, morbidity, and mortality of neonatal necrotizing enterocolitis in China, with special emphasis on determining the predictors of necrotizing enterocolitis associated mortality. We identified neonates as having necrotizing enterocolitis if they met the accepted diagnostic criterion. Data pertaining to antenatal period, labor and birth, and the postnatal course of illness were collected. Multivariate analysis and logistic regression were used to analyze the risk factors. There were 1167 cases of necrotizing enterocolitis identified from the 95 participating NICUs in mainland China in 2011, with the incidence of 2.50% and 4.53% in LBW (birth weight <2500 g) and VLBW (birth weight <1500 g) infants, respectively. Stage 1, 2 and 3 diseases were noted in 51.1%, 30.3% and 18.6% of cases respectively. The mortality from stage 2 and 3 necrotizing enterocolitis in this cohort was 41.7%. In VLBW infants, the important risk factors for mortality were small for gestation age (OR: 5.02, 95% CI 1.73-14.6; P = 0.003) and stage 3 NEC (OR: 8.09, 95% CI 2.80-23.3, P < 0.001). In moderate LBW infants (birth weight 1500-2499 g), the risk factors identified for mortality were sepsis during hospitalization (OR...Continue Reading

Citations

Mar 21, 2018·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Yang YangRui Cheng
Apr 6, 2018·Journal of Pediatric Gastroenterology and Nutrition·Kristen H ShanahanCamilia R Martin
Jan 7, 2020·Journal of Population Therapeutics and Clinical Pharmacology Journal De La Thérapeutique Des Populations Et De La Pharamcologie Clinique·Mohamed Shawky ElfarargyHany Abd Elfattah Elhady
Jun 11, 2019·Gastroenterology Research and Practice·Kewei WangKarl G Sylvester
Apr 14, 2019·Anaerobe·S Schönherr-Hellec, J Aires

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