PMID: 1919897Oct 1, 1991

Necrotizing enterocolitis in very low birth weight infants: biodemographic and clinical correlates. National Institute of Child Health and Human Development Neonatal Research Network

The Journal of Pediatrics
R D UauyL L Wright


We studied the occurrence of necrotizing enterocolitis in 2681 very low birth weight infants during an 18-month period to characterize the biodemographic and clinical correlates. Proven necrotizing enterocolitis (Bell stage II and beyond) occurred in 10.1% of study infants; necrotizing enterocolitis was suspected in 17.2% of study infants. Positivity of blood cultures was related to necrotizing enterocolitis staging. The mortality rate increased only for stage III necrotizing enterocolitis (54% died). Logistic regression identified medical center of birth, race, gender, birth weight, maternal hemorrhage, duration of ruptured membranes, and cesarean section as significant risk factors. For one center the odds ratio was 3.7, whereas for another center it was only 0.3. For black boys, the odds ratio was 2.3 relative to nonblack boys; for girls, race did not affect prevalence of necrotizing enterocolitis. Age at onset was related to birth weight and gestational age. Intercenter differences in necrotizing enterocolitis prevalence were related to time required to regain birth weight and other indicators of fluid management. Gram-positive organisms predominated in positive blood cultures for stage I and II necrotizing enterocolitis; e...Continue Reading


Sep 28, 2013·Pediatric Surgery International·Sadık YurttutanUğur Dilmen
Oct 24, 2001·Indian Journal of Pediatrics·A Kulkarni, R Vigneswaran
Oct 8, 2005·Pediatric Surgery International·Renu SharmaMonica Sharma
May 7, 2008·Pediatric Surgery International·Miguel Sáenz de Pipaón MarcosJosé Quero Jiménez
Apr 12, 2008·World Journal of Pediatrics : WJP·Vijai D UpadhyayaD K Gupta
Jul 28, 2013·Early Human Development·Valentina BozzettiDiego Gazzolo
Feb 29, 2000·Journal of Pediatric Surgery·D J Ledbetter, S E Juul
Mar 6, 2004·Seminars in Neonatology : SN·Jane S Lee, Richard A Polin
Nov 18, 2000·Biochimica Et Biophysica Acta·L W Tjoelker, D M Stafforini
May 26, 2006·The New England Journal of Medicine·Alan W Flake
Apr 1, 1994·Paediatric and Perinatal Epidemiology·R E McKeownT L Austin
Jun 1, 1995·Journal of Paediatrics and Child Health·R TobianskyM Veddovi
Aug 24, 2006·Journal of Paediatrics and Child Health·Amuchou S SoraishamReginald S Sauve
Aug 23, 2008·Journal of Paediatrics and Child Health·Jörg ErschHans Ulrich Bucher
Nov 13, 2009·Nutrition Reviews·Lars Bode
Jul 20, 2004·Clinical Microbiology Reviews·David Kaufman, Karen D Fairchild
Aug 23, 2005·Archives of Disease in Childhood. Fetal and Neonatal Edition·Jon DorlingAlison Leaf
Apr 22, 1999·Archives of Disease in Childhood. Fetal and Neonatal Edition·I H GewolbP Panigrahi
Aug 17, 1999·Archives of Disease in Childhood. Fetal and Neonatal Edition·M E CampbellD C Mayes
Mar 7, 2006·Postgraduate Medical Journal·J W L Puntis
Jul 10, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·Melissa D HalpernBohuslav Dvorak
Oct 6, 2009·BMC Pediatrics·Alison LeafPeter Brocklehurst
May 15, 2013·Italian Journal of Pediatrics·Giovanni BaroneEnrico Zecca
Jan 1, 1996·Journal of Perinatal Medicine·M MartellG Beltrami
Apr 15, 2008·World Journal of Gastroenterology : WJG·Kareena-L SchnablMichael-T Clandinin
May 16, 2012·Advances in Nutrition·Lars Bode, Evelyn Jantscher-Krenn
Jan 15, 2013·ISRN Gastroenterology·Thomas Peter Fox, Charles Godavitarne
Sep 12, 2008·Journal of Perinatology : Official Journal of the California Perinatal Association·R L MossK G Sylvester
Jan 22, 2011·Journal of Perinatology : Official Journal of the California Perinatal Association·M El-DibH Aly
Feb 1, 2012·Journal of Perinatology : Official Journal of the California Perinatal Association·C W WoodsQ Yang
Oct 2, 2014·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Aaron PitzeleThomas Havranek
Jul 24, 2012·Seminars in Perinatology·Edmund F La Gamma, Jonathan Blau
Apr 23, 2013·Journal of Obstetric, Gynecologic, and Neonatal Nursing : JOGNN·Sheila M GephartPamela G Reed
Jan 5, 2011·The Journal of Nutritional Biochemistry·Richard H SiggersPer T Sangild

Related Concepts

Gram-Positive Bacteria
Tissue Membrane
Multicenter Trials
African Continental Ancestry Group
Enterocolitis, Necrotizing
Prenatal Care
Human Development
Kidney Failure, Chronic
Very Low Birth Weight

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Synapse Loss as Therapeutic Target in MS

As we age, the number of synapses present in the human brain starts to decline, but in neurodegenerative diseases this occurs at an accelerated rate. In MS, it has been shown that there is a reduction in synaptic density, which presents a potential target for treatment. Here is the latest research on synapse loss as a therapeutic target in MS.

Artificial Intelligence in Cardiac Imaging

Artificial intelligence (ai) techniques are increasingly applied to cardiovascular (cv) medicine in cardiac imaging analysis. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

Social Learning

Social learning involves learning new behaviors through observation, imitation and modeling. Follow this feed to stay up to date on the latest research.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Single Cell Chromatin Profiling

Techniques like ATAC-seq and CUT&Tag have the potential to allow single cell profiling of chromatin accessibility, histones, and TFs. This will provide novel insight into cellular heterogeneity and cell states. Discover the latest research on single cell chromatin profiling here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.