Necrotizing enterocolitis is one disease with many origins and potential means of prevention

Pathophysiology : the Official Journal of the International Society for Pathophysiology
P V Gordon, Jonathan R Swanson

Abstract

The field of necrotizing enterocolitis (NEC) research has been in existence for over 60 years. During the first five decades little progress in NEC prevention and no definitive progress in treatment was achieved. One of the major determinants of this ineffectiveness may have been a global propensity to lump NEC into a single disease entity rather than a spectrum of diseases with a common outcome. The driver of this philosophy was most likely statistical, in that researchers desired large cohorts to optimize statistical power. Additionally, in the past quarter century, our preterm NEC cohorts were (and in some cases still are) contaminated with spontaneous intestinal perforations (SIP). This completely different acquired neonatal intestinal disease (ANID) markedly alters clinical characteristics and outcomes in NEC cohorts and subsets if not addressed. Unfortunately, cohort size has been proven to be less important than data quality when it comes to NEC over this last decade of research. Emerging progress in NEC prevention has been greatly enhanced as a result of dividing well-defined NEC into subsets of disease origin and investigating these entities individually. The purpose of this review is to offer the bedside clinician a c...Continue Reading

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Citations

Sep 30, 2014·Journal of Perinatology : Official Journal of the California Perinatal Association·J R Swanson
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