Necrotizing Fasciitis Following Herpes Zoster Ophthalmicus in an Immunocompromised Patient

Case Reports in Ophthalmological Medicine
Grazia Maria CozzupoliBenedetto Falsini

Abstract

Necrotizing fasciitis (NF) is a rare infection that spreads rapidly along the subcutaneous soft tissue planes. NF rarely involves the periorbital region due to the excellent blood supply of this region. We report a case of periorbital necrotising fasciitis following herpes zoster (HZ) in an immunocompromised 70-year-old patient with a dramatically rapid evolution into septic shock. In our patient, the surprisingly rapid spread of the bacterial superinfection led the periorbital cellulitis to turn into frank NF within 2 hours, with an overwhelming evolution. Despite the prompt start of a systemic antibiotic therapy and the immediate surgical intervention, the patient had a septic shock; she was treated in ITU for 31 days and then discharged to a medical ward and eventually died for a mix of complications of the medical treatment and comorbidities. This case is unique because any documented cases of periorbital NF triggered by HZ had never led to a septic shock and death. Ophthalmologists should be aware that even common skin lesions caused by shingles can determine a dramatic clinical picture, in presence of predisposing factors.

References

Jan 25, 1996·The New England Journal of Medicine·A L Bisno, D L Stevens
Aug 6, 1998·Clinical and Experimental Dermatology·P JarrettF Oliver
Jun 24, 2000·The American Journal of Medicine·G S SewellS R Jones
Nov 13, 2001·Eye·B PalR F Walters
Nov 5, 2002·Ophthalmology·Jason A LuksichMorris E Hartstein
Sep 12, 2003·Emerging Infectious Diseases·Stephanie H FactorAnne Schuchat
Jul 26, 2005·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Kamaljit S Balaggan, Sacha I Goolamali
Sep 26, 2006·Ophthalmology·Victor M ElnerAdam S Hassan
Nov 10, 2009·The British Journal of Ophthalmology·Davide LazzeriMarcello Pantaloni
Mar 24, 2010·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Valerie ByrnsideRaffi Gurunluoglu
Jul 27, 2011·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Victoria FungPaolo Longhi
Jun 14, 2014·The Journal of Craniofacial Surgery·Gary LinkovJeffrey C Liu
May 10, 2017·Open Forum Infectious Diseases·Kimiyasu ShirakiUNKNOWN Miyazaki Dermatologist Society
Oct 1, 2017·Neurologic Clinics·Christopher L Kramer

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Methods Mentioned

BETA
dissection
biopsies
amputation

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