Necrotizing fasciitis: risk factors of mortality

Risk Management and Healthcare Policy
Patcharin KhamnuanApichat Tantraworasin

Abstract

Necrotizing fasciitis (NF) is a serious infection of skin and soft tissues that rapidly progresses along the deep fascia. It becomes a fatal soft tissue infection with high mortality rate if treatment is delayed. Early diagnosis for emergency surgical debridement and broad-spectrum antibiotic therapy were the optimal treatments to reduce the mortality rate of NF. The aim of this study was to identify risk factors that increased the mortality rate in patients with NF under routine clinical practices. A retrospective cohort study was performed at three general hospitals located in northern Thailand. All medical records of patients with surgically confirmed NF treated between January 2009 and December 2012 were reviewed. Clinical predictors for mortality were analyzed using multivariable risk regression analysis. Of a total of 1,504 patients with a diagnosis of NF, 19.3% (n=290) died in hospital and 80.7% (n=1,214) survived. From multivariable analysis, being female (risk ratio [RR] =1.37, 95% confidence interval [CI] =1.01-1.84); age >60 (RR=1.39, 95% CI =1.25-1.53); having chronic heart disease (RR=1.64, 95% CI=1.18-2.28), cirrhosis (RR =2.36, 95% CI=1.70-3.27), skin necrosis (RR =1.22, 95% CI=1.15-1.28), pulse rate >130/min (RR...Continue Reading

Citations

Aug 11, 2016·World Journal of Emergency Surgery : WJES·Gaby JabbourHassan Al-Thani
Jun 2, 2016·The Journal of Infectious Diseases·Federica AndreoniAnnelies S Zinkernagel
Jul 24, 2018·Case Reports in Infectious Diseases·Alexandre NehmeHicham G Abdel Nour
Apr 30, 2017·The British Journal of Dermatology·E AudureauUNKNOWN Henri Mondor Hospital Necrotizing Fasciitis group

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