Necrotizing tracheobronchitis following high frequency ventilation: effect of hydrocortisone

Pediatric Pathology
L CorderoD Gardner

Abstract

A piglet model of acute respiratory failure was used to determine whether necrotizing tracheobronchitis (NTB) produced during high-frequency pneumatic flow interrupter (HFFI) ventilation could be attenuated by prior administration of 2 mg/kg hydrocortisone IV. Fourteen piglets (means age 3.6 days, means wt 1.4 kg) were anesthetized and paralyzed before saline lung lavage. The animals were randomly assigned to either placebo (P) or hydrocortisone (H) group. Continuous HFFI (10 Hz) was interrupted five times per minute by a 1-second deflationary pause. All animals were kept on 1.0 FI02 with ventilators adjusted to maintain adequate arterial blood gases. Airway pressures were similar for both groups. After 8 hours of ventilation the animals were sacrificed and their lungs inflated with formalin to 40 cm H2O. Sections were obtained from trachea, carina, main stem, and peripheral bronchi. A total airway injury (TAIS) was calculated by a pathologist unaware of treatment assignment. There was a significant difference (p less than 0.01, Wilcoxon rank sum) in TAIS scores between P (means 21.3) and H (means 7.8). In five out of seven P animals and in one out of seven H animals, NTB was severe and extended to the hilar bronchi. Although N...Continue Reading

References

Apr 1, 1986·Journal of Applied Physiology·D SheppardJ E Thompson
Sep 10, 1987·The New England Journal of Medicine·H L Malech, J I Gallin
Oct 1, 1988·American Journal of Diseases of Children·J B HansonL L Fan
Nov 1, 1987·Pediatric Pulmonology·M C Mammel, S J Boros
Jul 1, 1986·The Journal of Pediatrics·S J BorosJ Ophoven
Oct 1, 1985·Critical Care Medicine·H KirpalaniE Cutz
Sep 1, 1984·Critical Care Medicine·J P OphovenS J Boros
Jul 14, 1983·The New England Journal of Medicine·L A MetlayJ R Milley
Jun 1, 1980·Acta Anaesthesiologica Scandinavica·B LachmannJ Vogel

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Citations

Jan 5, 2010·International Journal of Pediatric Otorhinolaryngology·S Zekic TomasI Kuzmic Prusac
Jan 7, 2011·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Patrick A Ross, Christopher J L Newth

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