Neddylating the guardian; Mdm2 catalyzed conjugation of Nedd8 to p53

Cell
J Wade Harper

Abstract

The tumor suppressor and transcriptional regulator p53 is perhaps one of the most regulated proteins in the cell nucleus and is acted upon by a variety of protein kinases, acetylases, ubiqutin ligases and hydrolases, and SUMO-conjugating enzymes. Now new work suggests a role for an additional modification-neddylation-in negative regulation of p53 transcriptional activity.

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Citations

Jul 4, 2006·Nature Reviews. Drug Discovery·Grzegorz NalepaJ Wade Harper
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