PMID: 8939177Nov 1, 1996Paper

Nedocromil sodium and airway inflammation in vivo and in vitro

The Journal of Allergy and Clinical Immunology
J L DevaliaR J Davies

Abstract

We conducted a series of studies investigating the antiinflammatory effects of nedocromil sodium, with particular reference to its effects on human bronchial epithelial cells and eosinophils in vitro and on eosinophils in vivo. Nedocromil sodium produced a dose-related inhibition of ozone-induced IL-8 release from human bronchial epithelial cells and also attenuated the release of granulocyte macrophage colony-stimulating factor, tumor necrosis factor-alpha, and soluble intercellular adhesion molecule 1. The culture medium from human bronchial epithelial cell cultures, containing the proinflammatory cytokines IL-8, granulocyte macrophage colony-stimulating factor, "regulated on activation, normal T expressed and secreted," IL-1 beta, and tumor necrosis factor-alpha, increased eosinophil chemotaxis and eosinophil adhesion to cultured human endothelial cells. The chemotaxis and increased adhesion were blocked in the presence of nedocromil sodium. The drug also abrogated the epithelial cell dysfunction (assessed as ciliary beat frequency) induced by the presence of activated eosinophils and blocked the release of eosinophil cationic protein from the eosinophils. We also conducted a double-blind placebo-controlled study of the effe...Continue Reading

Citations

Feb 6, 1999·Journal of Perianesthesia Nursing : Official Journal of the American Society of PeriAnesthesia Nurses·J L Rau
May 19, 2010·Expert Review of Respiratory Medicine·Peter J Helms
Dec 1, 2017·Frontiers in Pharmacology·Ajantha SinniahRoderick J Flower
Aug 13, 2004·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Iwona StelmachPiotr Kuna
Jun 19, 2010·Arteriosclerosis, Thrombosis, and Vascular Biology·Samia YazidRoderick J Flower
Nov 9, 2002·Autonomic & Autacoid Pharmacology·K M Ellis, J R Fozard

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