PMID: 8607565Oct 1, 1995Paper

Nedocromil sodium reduces allergen-induced plasma extravasation in the guinea pig nasal mucosa by inhibition of tachykinin release

Allergy
P JavdanP Geppetti

Abstract

The effect of topically applied (10 microliters) nedocromil sodium (NS) and sodium cromoglycate (CS) on the plasma extravasation induced by local application of ovalbumin (5%, 10 microliters) into the respiratory nasal mucosa of sensitized guinea pigs pretreated with the neutral endopeptidase inhibitors, phosphoramidon, was studied. Topical NS (220 nmol, 10 microliters) reduced by 57% the Evans blue dye extravasation caused by local application of ovalbumin into the nasal mucosa, whereas CS (220 nmol, 10 microliters) was without effect. The tachykinin NK1 receptor antagonist CP-99994 (2 mumol/kg, i.v.) reduced by 45% the plasma extravasation induced by antigen challenge. The combination of NS and CP-99994 did not increase further the inhibition caused by NS alone. Plasma extravasation evoked by instillation of bradykinin (50 nmol), which causes this response by releasing tachykinins from sensory nerves, was markedly reduced by NS, but not by CS. Plasma extravasation evoked by installation of substance P, which acts directly on the endothelial cells, was not affected by NS. We conclude that the reduction by NS of the plasma extravasation induced by antigen challenge in the nasal mucosa of sensitized guinea pigs is due to the inh...Continue Reading

References

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Jan 1, 1995·Ocular Immunology and Inflammation·P JavdanP Geppetti

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Citations

Mar 10, 2004·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·E F WillisM K Church
May 7, 2002·American Journal of Respiratory and Critical Care Medicine·Elizabeth L J Van RensenPeter J Sterk
Dec 17, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Ghazal VessalSoliman Mohammadi Samani
Jan 1, 1996·Allergy·I G Knottnerus, P A Riley
Feb 13, 2001·British Journal of Pharmacology·P AhluwaliaM K Church
Apr 15, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·P H VerinB Mortemousque

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