Need for a Judicious Use of Nonsteroidal Anti-inflammatory Drugs to Avoid Community-Acquired Acute Kidney Injury

The Annals of Pharmacotherapy
Amy Barton PaiAndrew S Narva

Abstract

Millions of Americans use over-the-counter analgesics on a daily basis, and nearly 100 million nonsteroidal anti-inflammatory drug (NSAID) prescriptions are filled per year. In high-risk patients, these medications can disrupt kidney hemodynamics and precipitate community-acquired acute kidney injury (CA-AKI). The risk of NSAID-associated CA-AKI increases 3- to 5-fold in patients taking renin-angiotensin system inhibitors and diuretics concurrently. CA-AKI increases the risk of developing chronic kidney disease (CKD) or accelerating progression of pre-existing CKD. Importantly, many cases of NSAID-induced CA-AKI may be avoided by identifying high-risk patients and providing patient and provider education on when to avoid these medications and minimize risk.

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Citations

Dec 12, 2018·Der Schmerz·J SchneiderJ Bolbrinker
Feb 23, 2020·Pharmacoepidemiology and Drug Safety·Prasad S Nishtala, Te-Yuan Chyou
Mar 21, 2019·Biology Open·Kingsley Chukwunonso UgwuagboMousumi Majumder
Jul 26, 2019·Acta Pharmacologica Sinica·Xiao-Ying LiaoGuo-Yu Pan
Jul 24, 2021·Kidney360·Erin F Barreto, Molly A Feely

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