Need for expanded HPV genotyping for cervical screening.

Papillomavirus Research
Jack Cuzick, Cosette M Wheeler

Abstract

The focus for HPV genotyping has largely been on types 16 and 18, based on their high prevalence in cervix cancer. However screening is focussed on the detection of high grade precursor lesions (CIN3 and CIN2), where other types have a greater role. While HPV16 retains its high predictive value in this context, HPV31 and especially HPV33 emerge as important types with higher positive predictive values (PPVs) than HPV18. Additionally full typing indicates that types 39, 56, 59 and 68 have much lower PPVs than types 16, 18, 31, 33, 35, 45, 51, 52 and 58 and they should be considered as 'intermediate risk' types, whereas type 66 should not be treated as having an increased risk. Available data are summarized to support this view.

Citations

Jul 8, 2019·Clinical Chemistry and Laboratory Medicine : CCLM·Xueliang WangHualiang Wang
Aug 31, 2019·Expert Review of Molecular Diagnostics·Yiqun Liao, Qingge Li
Aug 14, 2019·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Saara KaresPaula Kujala
Nov 2, 2019·Journal of Clinical Microbiology·Anja Oštrbenk ValenčakMario Poljak
Sep 7, 2019·International Journal of Cancer. Journal International Du Cancer·Mark H StolerThomas C Wright
Apr 7, 2020·International Journal of Cancer. Journal International Du Cancer·Remila RezhakeMarc Arbyn
Sep 14, 2018·Journal of Clinical Microbiology·Anja OštrbenkMario Poljak
Jun 26, 2020·Frontiers in Cellular and Infection Microbiology·María Guadalupe Flores-MiramontesAdriana Aguilar-Lemarroy
Apr 5, 2020·Viruses·Mariel A Oyervides-MuñozMaría L Garza-Rodríguez
Mar 15, 2020·International Journal of Cancer. Journal International Du Cancer·Jack CuzickUNKNOWN New Technologies for Cervical Cancer Screening Working Group
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Methods Mentioned

BETA
genotyping

Software Mentioned

ATHENA

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