Need for Flexible Adjustment of the Treatment Schedule for Aprepitant Administration against Erlotinib-Induced Refractory Pruritus and Skin Rush

Case Reports in Oncology
Nobuhiko SekiKiyotaka Watanabe

Abstract

Common dermatological side-effects associated with erlotinib, epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI), include pruritus and skin rash, which are mediated by substance P, leading to the occasional discontinuation of cancer treatment. Aprepitant is an antagonist of neurokinin-1 receptor, through which substance P activates the pruritogens. Thus, aprepitant is expected to offer a promising option for the treatment of erlotinib-induced pruritus. However, the appropriate treatment schedule for aprepitant administration is under consideration. Here, we discuss the need for flexible adjustment of the treatment schedule for aprepitant administration against erlotinib-induced refractory pruritus and skin rush. A 71-year-old female smoker presented with stage IV EGFR-mutated lung adenocarcinoma. She was started on erlotinib at 150 mg/day. However, by 28 days, severe pruritus and acneiform skin rush resistant to standard therapies occurred, resulting in the interruption of erlotinib therapy. After recovery, she was restarted on erlotinib at 100 mg/day. However, severe pruritus and skin rush developed again within 2 weeks. Then, we started the first 3-day dose of aprepitant (125 mg on day 1, 80 mg on day 3, ...Continue Reading

References

Nov 22, 2005·Dermatologic Therapy·Joanna Wallengren
Oct 3, 2009·The New England Journal of Medicine·Arnaud Duval, Louis Dubertret
Jun 15, 2010·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Bruno VincenziGiuseppe Tonini
Jul 28, 2010·The New England Journal of Medicine·Bruno VincenziDaniele Santini
Nov 3, 2010·The British Journal of Dermatology·N BookenJ Utikal
Feb 4, 2011·The New England Journal of Medicine·Peter Arne GerberBernhard Homey
Dec 20, 2011·Journal of the American Academy of Dermatology·Tiago TorresMargarida Lima
Sep 22, 2012·The Lancet Oncology·Olivier Mir, Romain Coriat
Oct 16, 2012·Journal of the American Academy of Dermatology·Barry LadizinskiElise A Olsen
Feb 13, 2014·Dermatologic Therapy·David Jiménez GalloMaría Eugenia Rodríguez Mateos
Sep 10, 2014·Journal of Medical Case Reports·Jose Javier Arenas VillafrancaAntonio Rueda Domínguez

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