Need for testing glucose tolerance in the early weeks of pregnancy

Indian Journal of Endocrinology and Metabolism
Seshiah VeeraswamyBalaji Vijayam

Abstract

This observational study aims to determine the frequency of occurrence of glucose intolerance in the early weeks of pregnancy. New World Health Organization 2013 guidelines recommends "A Single Step Procedure" (SSP) as an option for diagnosing gestational diabetes mellitus (GDM). Pregnant women attending 131 prenatal clinics across India for the first time underwent SSP consisting of administration of 75 goral glucose irrespective of the last meal timing and to diagnose GDM with 2 h plasma glucose (PG) value ≥7.8 mmol/L (7.8 mmol/L). In a cohort of n = 11,785, the number of pregnant women who underwent the test in first, second, and third trimesters were 4300, 4632, and 2853, respectively. Documented blood glucose values were available for 9282 pregnant women and in them, diagnosis of GDM was made in 740 (8%). Among them, 233 (31.5%), 320 (43.2%), and 187 (25.3%) were in the first, second and third trimesters, respectively. Positive family history of diabetes (43%) and history of fetal loss in previous pregnancy (27%) was more common in women diagnosed with GDM in the first trimester compared to GDM diagnosed in the second or third trimester. Manifestation of GDM in the early weeks of gestation is quite common.

References

Apr 1, 1991·Diabetes Care·D M SuperS C Kalhan
Feb 26, 2000·Diabetic Medicine : a Journal of the British Diabetic Association·M E GriffinR G Firth
Jun 24, 2003·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Jose L BarthaRafael Comino-Delgado
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Feb 13, 2007·Diabetes Research and Clinical Practice·V SeshiahManjula Datta
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Jan 22, 2009·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Veerasamy SeshiahAnil Kapur
Oct 31, 2009·Lancet·Ambady RamachandranChamukuttan Snehalatha

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