Needle-compatible miniaturized optoelectronic sensor for pancreatic cancer detection

Science Advances
Seung Yup LeeMary-Ann Mycek

Abstract

Pancreatic cancer is one of the deadliest cancers, with a 5-year survival rate of <10%. The current approach to confirming a tissue diagnosis, endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA), requires a time-consuming, qualitative cytology analysis and may be limited because of sampling error. We designed and engineered a miniaturized optoelectronic sensor to assist in situ, real-time, and objective evaluation of human pancreatic tissues during EUS-FNA. A proof-of-concept prototype sensor, compatible with a 19-gauge hollow-needle commercially available for EUS-FNA, was constructed using microsized optoelectronic chips and microfabrication techniques to perform multisite tissue optical sensing. In our bench-top verification and pilot validation during surgery on freshly excised human pancreatic tissues (four patients), the fabricated sensors showed a comparable performance to our previous fiber-based system. The flexibility in source-detector configuration using microsized chips potentially allows for various light-based sensing techniques inside a confined channel such as a hollow needle or endoscopy.

References

Nov 1, 1991·British Journal of Anaesthesia·K J ReynoldsJ T Moyle
Sep 24, 2005·Journal of Biomedical Optics·Adrien Ming Jer WangRebekah Anna Drezek
Oct 26, 2005·Gastrointestinal Endoscopy·Shyam VaradarajuluMohamad A Eloubeidi
Feb 20, 2007·Biophysical Journal·Dizem AriflerRebecca Richards-Kortum
Jan 1, 2008·Journal of Biomedical Optics·Malavika ChandraMary-Ann Mycek
Jun 11, 2008·Optics Express·Yalin Ti, Wei-Chiang Lin
Nov 13, 2009·Optics Express·Robert H WilsonMary-Ann Mycek
Mar 10, 2010·Journal of Biomedical Optics·Malavika ChandraMary-Ann Mycek
Jul 2, 2010·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Stephen C KanickJoachim G J V Aerts
Nov 1, 1995·Applied Optics·I S SaidiF K Tittel
Feb 2, 2011·Journal of Biomedical Optics·Liang LimJames W Tunnell
Jan 11, 2014·Biomedical Optics Express·Seung Yup LeeMary-Ann Mycek
Jan 28, 2014·Biomedical Optics Express·William R LloydMary-Ann Mycek
Dec 11, 2014·Nature Communications·Claire M LochnerAna C Arias
Jun 27, 2017·Nature Biomedical Engineering·Seok Hyun Yun, Sheldon J J Kwok
Aug 12, 2017·Advanced Functional Materials·Jeonghyun KimJohn A Rogers
Oct 24, 2017·Nature Biomedical Engineering·Lei ZhangLev T Perelman
May 23, 2018·World Journal of Gastroenterology : WJG·Lulu ZhangAlina Stoita
Nov 9, 2018·Proceedings of the National Academy of Sciences of the United States of America·Yasser KhanAna C Arias

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy
fluorescence spectroscopy
light scattering
pancreatectomy
chip
chips
biopsies

Software Mentioned

R Foundation
Ansys
Zemax
R package

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.