Needle Revision With 5-fluorouracil for the Treatment of Ahmed Glaucoma Valve Filtering Blebs: 5-Fluoruracil Needling Revision can be a Useful and Safe Tool in the Management of Failing Ahmed Glaucoma Valve Filtering Blebs

Journal of Glaucoma
Luciano QuarantaAnastasios G P Konstas

Abstract

To determine the outcome of needling with adjunctive 5-fluorouracil (5-FU) in patients with a failing Ahmed glaucoma valve (AGV) implant, and to identify predictors of long-term intraocular pressure (IOP) control. A prospective observational study was performed on consecutive patients with medically uncontrolled primary open-angle glaucoma (POAG) with AGV encapsulation or fibrosis and inadequate IOP control. Bleb needling with 5-FU injection (0.1 mL of 50 mg/mL) was performed at the slit-lamp. Patients were examined 1 week following the needling, and then at months 1, 3, and 6. Subsequent follow-up visits were scheduled at 6-month intervals for at least 2 years. Needling with 5-FU was repeated no more than twice during the first 3 months of the follow-up. Procedure outcome was determined on the basis of the recorded IOP levels. Thirty-six patients with an encapsulated or fibrotic AGV underwent 67procedures (mean 1.86 ± 0.83). Complete success, defined as IOP ≤ 18 mm Hg without medications, was obtained in 25% at 24 months of observation. The cumulative proportion of cases achieving either qualified (ie, IOP ≤ 18 mm Hg with medications) or complete success at 24 months of observation was 72.2%. In a univariate Cox proportional h...Continue Reading

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Citations

Dec 19, 2018·Current Opinion in Ophthalmology·Jenny Chen, Steven J Gedde
Nov 1, 2017·Journal of Glaucoma·Yadollah EslamiAli Izadi
Aug 1, 2019·Cutaneous and Ocular Toxicology·Burak ErdemNimet Yesim Ercalik
Jun 27, 2020·Journal of Glaucoma·Roxana Becerril-CazaderoGabriel Lazcano-Gomez
Jun 11, 2019·Korean Journal of Ophthalmology : KJO·Seong Eun LeeChang Sik Kim
Aug 28, 2020·International Ophthalmology·Maryam YadgariFatemeh Vafaei
Aug 13, 2017·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Kevin Kaplowitz, James C Tsai
Aug 11, 2017·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Luciano QuarantaIvano Riva
Apr 2, 2020·Case Reports in Ophthalmology·Ikhwanuliman PuteraWidya Artini

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