Needle-type organic electrochemical transistor for spatially resolved detection of dopamine.

Mikrochimica Acta
Federica MarianiWolfgang Schuhmann

Abstract

In this work, the advantages of carbon nanoelectrodes (CNEs) and orgonic electrochemical transistors (OECTs) were merged to realise nanometre-sized, spearhead OECTs based on single- and double-barrel CNEs functionalised with a conducting polymer film. The needle-type OECT shows a high aspect ratio that allows its precise positioning by means of a macroscopic handle and its size is compatible with single-cell analysis. The device was characterised with respect to its electrolyte-gated behaviour and was employed as electrochemical sensor for the proof-of-concept detection of dopamine (DA) over a wide concentration range (10-12-10-6 M). Upon application of fixed drain and gate voltages (Vd = - 0.3 V, Vg = - 0.9 V, respectively), the nano-sized needle-type OECT sensor exhibited a linear response in the low pM range and from 0.002 to 7 μM DA, with a detection limit of 1 × 10-12 M. Graphical abstract.

References

Apr 6, 2001·Analytical Chemistry·W H HuangJ K Cheng
Sep 23, 2003·Clinical Chemistry·Donita L RobinsonR Mark Wightman
Dec 19, 2006·Trends in Neurosciences·Gordon W Arbuthnott, Jeff Wickens
Mar 21, 2007·Trends in Neurosciences·Paolo CalabresiMassimiliano Di Filippo
Nov 14, 2007·Archives of Neurology·Nora D VolkowFrank Telang
Oct 6, 2009·Analytica Chimica Acta·Maura PerryRobert T Kennedy
Jun 10, 2011·Biosensors & Bioelectronics·Hao TangFeng Yan
Jan 9, 2013·Biochimica Et Biophysica Acta·Giuseppe TarabellaSalvatore Iannotta
Jan 9, 2013·Methods in Molecular Biology·James G RobertsLeslie A Sombers
Sep 11, 2013·Chemical Society Reviews·Luisa TorsiGerardo Palazzo
Oct 17, 2013·Frontiers in Neural Circuits·Ja-Hyun Baik
Feb 26, 2015·Analytical Chemistry·Hillary R ReesB Jill Venton
Apr 17, 2015·Nanotechnology·Sean E Anderson, Haim H Bau
Oct 31, 2015·Analytical Chemistry·Magdalena MichalakWojciech Nogala
Jan 16, 2016·Oxidative Medicine and Cellular Longevity·Hugo Juárez OlguínGerardo Barragán Mejía
Oct 16, 2016·Scientific Reports·Isacco GualandiBeatrice Fraboni
Jan 31, 2017·Advanced Materials·Marcel BraendleinRóisín M Owens
Sep 21, 2017·Nature Communications·Ren RenYuri Korchev
Dec 22, 2017·Advanced Materials·Mary J DonahueGeorge G Malliaras
Feb 21, 2018·Lab on a Chip·V F CurtoR M Owens
Apr 14, 2018·Nature Communications·Matteo GhittorelliFabrizio Torricelli
Jun 10, 2018·Biosensors & Bioelectronics·Nileshi SarafSudipta Seal
Aug 15, 2018·International Journal of Molecular Sciences·Krishna FeronPaul C Dastoor
Oct 27, 2018·ACS Applied Materials & Interfaces·Liang XueJoshua B Edel
Nov 23, 2018·NeuroImage·David MederHartwig Roman Siebner
Jan 20, 2019·Nature Communications·Rachel N LippertHeiko Backes
Feb 6, 2019·Nano Letters·Quentin ThiburceAlasdair J Campbell
Mar 13, 2019·Advanced Materials·Erica ZeglioAnna Herland
Aug 21, 2019·Nature Materials·Bryan D PaulsenJonathan Rivnay
Aug 24, 2019·Small·Pasquale D'AngeloSalvatore Iannotta
Sep 7, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·I GualandiB Fraboni

❮ Previous
Next ❯

Methods Mentioned

BETA
scanning
X-ray

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved