Nefazodone attenuates the behavioral and neurochemical effects of ethanol

Alcohol
P OlaussonJ A Engel

Abstract

This study evaluated the influence of nefazodone, a combined 5-HT2A receptor antagonist and 5-HT reuptake inhibitor, on the behavioral and neurochemical effects of ethanol in nonselected male Wistar rats. In microdialysis experiments, ethanol (2.5 g/kg, i.p.) increased extracellular accumbal dopamine levels by 36% (p = 0.0073) compared to baseline levels, and elevated the maximal DOPAC and HVA levels by 26% (p = 0.0093) and 52% (p = 0.0010), respectively, Nefazodone (50 mg/kg, s.c.) per se increased accumbal dopamine levels by 28% (p = 0.0199) but, when injected 40 min before ethanol, reduced the ethanol-induced elevation of accumbal dopamine overflow (p = 0.0132) and decreased the ethanol-induced HVA levels (p = 0.0159). In an ethanol(6% v/v)/water free-choice paradigm, nefazodone (50 mg/kg, s.c.) decreased ethanol intake by 51% (p = 0.0251) and preference by 22% (p = 0.0251) in high- but not low-preferring rats from a nonselected Wistar strain. These results show that nefazodone modulates the mesolimbic dopamine system in a dopamine activity-dependent manner, and influences the neurochemical and behavioral effects of ethanol in the rat.

References

Jan 1, 1992·Pharmacology & Toxicology·G SerraG L Gessa
Jan 1, 1992·Clinical Neuropharmacology·J A EngelB Söderpalm
Oct 1, 1991·Drug and Alcohol Dependence·L H Gold, R L Balster
Sep 1, 1991·Pharmacopsychiatry·T F MeertP A Janssen
Oct 9, 1990·European Journal of Pharmacology·K M WozniakM Linnoila
Jun 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·P D SuzdakS M Paul
Jul 1, 1988·Brain Research Bulletin·X M Guan, W J McBride
Jul 18, 1989·European Journal of Pharmacology·Y L Hurd, U Ungerstedt
Jun 19, 1989·Neuroscience Letters·A Imperato, L Angelucci
Apr 12, 1989·European Journal of Pharmacology·S M SorensenM G Palfreyman
Oct 1, 1986·Physiology & Behavior·J P Kroon, A L Riley
Aug 1, 1995·Pharmacology, Biochemistry, and Behavior·A D Campbell, W J McBride
Jan 1, 1995·Life Sciences·C J SchmidtM G Palfreyman
Sep 15, 1994·Biological Psychiatry·D LeMarquandC Benkelfat
Oct 1, 1994·Alcoholism, Clinical and Experimental Research·J BalldinB Söderpalm
Sep 1, 1994·Biological Psychiatry·D LeMarquandC Benkelfat
Sep 1, 1994·Archives of General Psychiatry·H R KranzlerM J Bohn
Jan 1, 1993·Brain Research. Brain Research Reviews·P W Kalivas
Oct 1, 1993·Pharmacology, Biochemistry, and Behavior·C Heidbreder, P De Witte
Nov 9, 1993·European Journal of Pharmacology·O BlomqvistB Söderpalm
Feb 1, 1993·Alcoholism, Clinical and Experimental Research·L J ChandlerF T Crews

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Citations

Mar 13, 2002·Pharmacology, Biochemistry, and Behavior·Peter OlaussonBo Söderpalm
Aug 2, 2002·Pharmacology, Biochemistry, and Behavior·María J NúñezManuel Freire-Garabal
Apr 16, 2004·Alcoholism, Clinical and Experimental Research·Carlos A Hernandez-AvilaHenry R Kranzler
Feb 14, 2007·Alcoholism, Clinical and Experimental Research·Martin ZackColin M MacLeod
Sep 17, 2004·Pharmacology & Therapeutics·Rueben A GonzalesWilliam M Doyon
Sep 6, 2011·Journal of Psychopharmacology·V Bess AramakisMartin Zack

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