Neferine, a Bisbenzylisoquinoline Alkaloid, Ameliorates Dextran Sulfate Sodium-Induced Ulcerative Colitis

The American Journal of Chinese Medicine
Xiaxia WuXiuping Chen

Abstract

Both the incidence and prevalence of ulcerative colitis (UC) are increasing throughout the world. Neferine, a natural alkaloid, demonstrated a variety of biological activities. In this study, the anti-inflammatory effect of neferine was investigated. Raw264.7 cells were stimulated with lipopolysaccharide (LPS) or LPS plus Z-VAD-fmk (Z-VAD). The inhibitory effect of neferine on secretion of nitrite, cytokines tumor necrosis factor alpha (TNF-[Formula: see text]) and interleukin 6 (IL-6), expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) was determined. The protective effect of neferine was investigated in dextran sulfate sodium (DSS)-induced UC mouse model. Neferine significantly inhibited LPS and LPS plus Z-VAD induced secretion of nitrite, cytokines, and expression of iNOS and COX-2. Oral administration of neferine (10[Formula: see text]mg/kg and 25[Formula: see text]mg/kg) significantly reduced DSS-induced mouse weight loss, decreased disease activity index (DAI) scores, improved colon pathological changes, and decreased plasma cytokines. In addition, neferine significantly inhibited the protein expression of iNOS, COX-2, receptor-interacting protein 1 (RIP1), RIP3, mixed lineage kinase domain-...Continue Reading

References

Aug 7, 1993·Lancet·N K Boughton-SmithS Moncada
Dec 22, 1998·The American Journal of Gastroenterology·R GuimbaudS Chaussade
Nov 17, 2009·European Journal of Pharmacology·Libo ZhaoJialing Wang
May 6, 2010·Immunopharmacology and Immunotoxicology·Francisco A Villa, Lena Gerwick
Sep 2, 2010·World Journal of Gastroenterology : WJG·Sahar K Hegazy, Mohamed M El-Bedewy
Aug 9, 2011·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Chenghui HuangZhiqiang Qin
Nov 6, 2012·Food Chemistry·Paramasivan PoornimaViswandha Vijaya Padma
Jan 1, 2013·Cardiovascular Toxicology·Gurusamy LalithaViswanadha Vijaya Padma
Jul 30, 2014·World Journal of Gastroenterology : WJG·Bruno César da SilvaGenoile Oliveira Santana
Aug 31, 2014·Drug Discovery Today·Andreas Koeberle, Oliver Werz
Oct 24, 2014·World Journal of Gastroenterology : WJG·Ping WanAi-Ping Bai
Aug 20, 2015·Critical Reviews in Food Science and Nutrition·Alessandra BordoniGuy Vergères
Jan 8, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Limei XuZhaojian Liu
Jan 16, 2016·International Immunopharmacology·Young Hee ChoiYoung-Won Chin
Apr 25, 2016·Best Practice & Research. Clinical Rheumatology·Hilde BrouwersAndreea Ioan-Facsinay
Sep 16, 2016·The American Journal of Chinese Medicine·Min-Jee KimMee Ree Kim
Sep 17, 2016·Gastrointestinal Endoscopy Clinics of North America·Deepa T PatilRobert D Odze
Dec 14, 2016·Annual Review of Pathology·Lorenzo GalluzziGuido Kroemer
Dec 16, 2016·Immunology and Cell Biology·Inbar ShlomovitzMotti Gerlic
Jan 4, 2017·The Journal of Clinical Investigation·Kosei Eguchi, Ryozo Nagai
May 13, 2017·Cell Death and Differentiation·Sasker GrootjansPeter Vandenabeele
May 22, 2017·The American Journal of Pathology·Gabrielle Fredman, Ira Tabas
Jul 1, 2017·The American Journal of Chinese Medicine·Dae-Seung KimSeung-Heon Hong
Aug 24, 2017·The American Journal of Chinese Medicine·Jin-Yi WanChun-Su Yuan
Aug 24, 2017·The American Journal of Chinese Medicine·Yan QiChunping Wan
Sep 28, 2017·The American Journal of Chinese Medicine·Jiaolin BaoChengwei He

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here