Negative and paranoid symptoms are associated with negative performance beliefs and social cognition in 22q11.2 deletion syndrome

Early Intervention in Psychiatry
Maude SchneiderStephan Eliez

Abstract

22q11.2 deletion syndrome (22q11.2DS) is a neurogenetic condition associated with an increased risk of developing schizophrenia. Previous studies have shown that negative symptoms represent the most specific clinical characteristic of psychosis in 22q11.2DS and are strongly associated with outcome. However, the psychological mechanisms associated with these symptoms in this population are poorly understood. In accordance with recent conceptualizations in the field of schizophrenia, the present study aims at investigating whether negative symptoms are associated with the presence of negative performance beliefs and cognitive deficits. Thirty-five participants with 22q11.2DS and 24 typically developing individuals aged between 11 and 24 years were included in the study. Self-reported schizotypal symptoms (cognitive-perceptual, paranoid, negative and disorganization symptoms) and dysfunctional beliefs (negative performance beliefs and need for approval) were assessed. Measures of processing speed, verbal memory, working memory, executive functioning and face recognition were also extracted from a broad cognitive evaluation protocol. Adolescents with 22q11.2DS reported significantly higher score on the negative dimension of the Sch...Continue Reading

References

Oct 26, 1999·Archives of General Psychiatry·K C MurphyM J Owen
Mar 10, 2001·Psychological Medicine·P A GaretyP E Bebbington
Feb 15, 2002·Lancet·Kieran C Murphy
Jul 29, 2004·Schizophrenia Bulletin·Nicholas C StefanisCostas N Stefanis
Feb 3, 2005·The British Journal of Psychiatry : the Journal of Mental Science·Kate D Baker, David H Skuse
Jun 23, 2005·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Neil A RectorNeal Stolar
Oct 14, 2005·Schizophrenia Bulletin·Philip D HarveyChristopher R Bowie
Nov 25, 2005·Child Neuropsychology : a Journal on Normal and Abnormal Development in Childhood and Adolescence·Ida Sue Baron
Feb 17, 2006·Schizophrenia Bulletin·Brian KirkpatrickStephen R Marder
Mar 12, 2008·Neuropsychology·Martin DebbanéStephan Eliez
Jul 23, 2008·Schizophrenia Bulletin·George Foussias, Gary Remington
Sep 5, 2008·Schizophrenia Research·Cara O'GrádaGary Donohoe
Jul 3, 2009·Journal of Clinical Psychology·Dimitri Perivoliotis, Corinne Cather
Oct 3, 2009·Journal of the American Academy of Child and Adolescent Psychiatry·Tamar GreenStephan Eliez
Oct 10, 2009·Research in Developmental Disabilities·Lena Niklasson, Christopher Gillberg
Dec 17, 2009·Journal of Psychiatric Research·William P HoranMichael F Green
Mar 24, 2010·The Australian and New Zealand Journal of Psychiatry·Linda E CampbellKieran C Murphy
Aug 31, 2010·Schizophrenia Research·Laura K ClarkPaul H Lysaker
May 17, 2011·The Journal of Pediatrics·Anne S BassettUNKNOWN International 22q11.2 Deletion Syndrome Consortium
Aug 6, 2013·Psychiatry Research·Gagan FervahaGary Remington

❮ Previous
Next ❯

Related Concepts

Related Feeds

22q11 Deletion Syndrome

22q11.2 deletion syndrome, also known as DiGeorge syndrome, is a congenital disorder caused by a partial deletion of chromosome 22. Symptoms include heart defects, poor immune system function, a cleft palate, complications related to low levels of calcium in the blood, and delayed development. Discover the latest research on this disease here.