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Negative autoregulation matches production and demand in synthetic transcriptional networks

bioRxiv

Nov 14, 2013

Elisa De FrancoRichard M. Murray

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Abstract

We propose a negative feedback architecture that regulates activity of artificial genes, or "genelets", to meet their output downstream demand, achieving robustness with respect to uncertain open-loop output production rates. In particular, we consider the case where the outputs of two ...read more

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Computer Software
Simulation
Regulation of Signaling
Cross Reactions
Nucleic Acids
Medical Devices
Research Study
Genes
Nucleic Acid Location
In Vitro [Publication Type]
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  • Negative autoregulation matches production and demand in synthetic transcriptional networks

    bioRxiv

    Nov 14, 2013

    Elisa De FrancoRichard M. Murray

    PMID: 990000430

    DOI: 10.1101/000430

    Abstract

    We propose a negative feedback architecture that regulates activity of artificial genes, or "genelets", to meet their output downstream demand, achieving robustness with respect to uncertain open-loop output production rates. In particular, we consider the case where the outputs of two ...read more

    Mentioned in this Paper

    Computer Software
    Simulation
    Regulation of Signaling
    Cross Reactions
    Nucleic Acids

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