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Negative autoregulation matches production and demand in synthetic transcriptional networks

bioRxiv

Nov 14, 2013

Elisa FrancoRichard M Murray

Abstract

We propose a negative feedback architecture that regulates activity of artificial genes, or “genelets”, to meet their output downstream demand, achieving robustness with respect to uncertain open-loop output production rates. In particular, we consider the case where the outputs of two ...read more

Mentioned in this Paper

Gene Regulatory Networks
Medical Devices
Nucleic Acids
Computer Software
In Vitro [Publication Type]
Regulation of Signaling
Transcription, Genetic
Simulation
Research Study
Cross Reactions
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Negative autoregulation matches production and demand in synthetic transcriptional networks

bioRxiv

Nov 14, 2013

Elisa FrancoRichard M Murray

PMID: 990000430

DOI: 10.1101/000430

Abstract

We propose a negative feedback architecture that regulates activity of artificial genes, or “genelets”, to meet their output downstream demand, achieving robustness with respect to uncertain open-loop output production rates. In particular, we consider the case where the outputs of two ...read more

Mentioned in this Paper

Gene Regulatory Networks
Medical Devices
Nucleic Acids
Computer Software
In Vitro [Publication Type]
Regulation of Signaling
Transcription, Genetic
Simulation
Research Study
Cross Reactions

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Paper Details
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