Negative consequences of early-life adversity on substance use as mediated by corticotropin-releasing factor modulation of serotonin activity

Neurobiology of Stress
Gina L ForsterMichael J Watt

Abstract

Early-life adversity is associated with increased risk for substance abuse in later life, with women more likely to report past and current stress as a mediating factor in their substance use and relapse as compared to men. Preclinical models of neonatal and peri-adolescent (early through late adolescence) stress all support a direct relationship between experiences of early-life adversity and adult substance-related behaviors, and provide valuable information regarding the underlying neurobiology. This review will provide an overview of these animal models and how these paradigms alter drug and alcohol consumption and/or seeking in male and female adults. An introduction to the corticotropin-releasing factor (CRF) and serotonin systems, their development and their interactions at the level of the dorsal raphe will be provided, illustrating how this particular stress system is sexually dimorphic, and is well positioned to be affected by stressors early in development and throughout maturation. A model for CRF-serotonin interactions in the dorsal raphe and how these influence dopaminergic activity within the nucleus accumbens and subsequent reward-associated behaviors will be provided, and alterations to the activity of this sys...Continue Reading

References

Jul 6, 1978·Psychopharmacology·B K AlexanderP F Hadaway
Jun 1, 1989·The International Journal of the Addictions·P A HarrisonG E Edwall
Oct 29, 1993·Annals of the New York Academy of Sciences·T S Gray
Jan 1, 1993·Pharmacology, Biochemistry, and Behavior·L L WeinholdJ H Jaffe
Feb 26, 1996·Brain Research. Developmental Brain Research·S Avishai-ElinerT Z Baram
Apr 1, 1997·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·J C ChenL Volicer
Jan 29, 2000·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·L G KirbyR J Valentino
Jul 5, 2001·Physiology & Behavior·K Björkqvist
Jan 17, 2002·Clinical Psychology Review·Tracy L Simpson, William R Miller
Nov 26, 2002·Behavioural Brain Research·Gaetano Di Chiara
Jul 31, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Shelly B FlagelTerry E Robinson
Feb 13, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Luise PernarRita J Valentino
Apr 16, 2004·Behavioural Brain Research·Therese A KostenPriscilla Kehoe
Oct 28, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Wendy J LynchJane R Taylor
Mar 1, 2005·European Journal of Pharmacology·Donald R GehlertTammy J Sajdyk
Mar 31, 2005·American Journal of Public Health·Danielle C OmpadSteffanie A Strathdee

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Citations

Aug 29, 2020·Nature Reviews. Gastroenterology & Hepatology·Arpana GuptaEmeran A Mayer
Mar 2, 2021·Frontiers in Human Neuroscience·Sophia C LevisTallie Z Baram
Apr 8, 2021·The European Journal of Neuroscience·Sophia C LevisStephen V Mahler

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Methods Mentioned

BETA
acetylation

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