Negative control of Candida albicans filamentation-associated gene expression by essential protein kinase gene KIN28

Current Genetics
Carol A WoolfordAaron P Mitchell

Abstract

The fungus Candida albicans can grow as either yeast or filaments, which include hyphae and pseudohyphae, depending on environmental conditions. Filamentous growth is of particular interest because it is required for biofilm formation and for pathogenesis. Environmentally induced filamentous growth is associated with expression of filamentation-associated genes, and both filamentous growth and associated gene expression depend upon several well-characterized transcription factors. Surprisingly, strains with reduced expression of many essential genes display filamentous growth under non-inducing conditions-those in which the wild type grows as yeast. We found recently that diminished expression of several essential protein kinase genes leads to both filamentous cell morphology and filamentation-associated gene expression under non-inducing conditions. Reduced expression of the essential protein kinase gene CAK1 promoted filamentation-associated gene expression and biofilm formation in strains that lacked key transcriptional activators of these processes, thus indicating that CAK1 expression is critical for both environmental and genetic control of filamentation. In this study, we extend our genetic interaction analysis to a seco...Continue Reading

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Citations

Jan 27, 2018·Journal of Fungi·Jigar V Desai
May 26, 2018·Current Genetics·Chang SuYang Lu

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Methods Mentioned

BETA
confocal microscopy

Software Mentioned

multiexperimental viewer
MeV

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