Negative correlation between D-dimer and homocysteine levels during pregnancy and the postpartum period: a prospective study

European Journal of Obstetrics, Gynecology, and Reproductive Biology
Berna HalilogluUmit Ozekici

Abstract

There have been conflicting data about the role of increased levels of homocysteine (Hcy) on haemostatic system. We aim to investigate prospectively the relation between serum Hcy levels and changes in haemostatic system in pregnancy and postpartum period. Sixty-eight healthy pregnant women were included in the study. Blood samples were obtained in the 11th gestational week, 25th gestational week, 32nd gestational week and postpartum 4th week. The haemoglobin levels, white blood cell count (WBC), platelet count, activated partial thromboplastin time (aPTT), prothrombin time (PT), fibrinogen, D-dimer, Hcy, vitamin B12, and folate levels were measured. Serum Hcy levels were negatively correlated with D-dimer levels (r = -0.57, p < 0.0001). The highest levels of D-dimer (1046.62 ± 322.01 ng/ml) were achieved in the third trimester and the lowest levels of serum Hcy (4.45 ± 1.23 mmol/l) were detected in the same trimester. In postpartum fourth week, D-dimer levels were decreased to normal levels (238.27 ± 198.59 ng/ml) while the serum Hcy levels were reached to the highest levels (7.99 ± 1.36 mmol/l). The negative correlation between Hcy and D-dimer levels may be a compensatory mechanism to maintain the normal haemostatic balance i...Continue Reading

References

Apr 21, 1999·Lancet·F R Rosendaal
Apr 24, 2003·Seminars in Thrombosis and Hemostasis·Margareta Hellgren
Sep 26, 2003·The Proceedings of the Nutrition Society·Valerie A Holmes
Jan 27, 2005·Journal of Thrombosis and Haemostasis : JTH·M EpineyP De Moerloose
Apr 6, 2005·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Ekaterina H Uchikova, Ilija I Ledjev
Feb 17, 2009·Thrombosis Research·Sabine Eichinger
Dec 1, 2009·Clinical Chemistry and Laboratory Medicine : CCLM·Anna KlajnbardSteen Stender

❮ Previous
Next ❯

Citations

Oct 30, 2016·Journal of Clinical Laboratory Analysis·Jiao-Mei GongYan-Xia He
Jun 21, 2017·American Journal of Hematology·Jessica A ReeseJames N George
Jul 13, 2018·Clinical Practice and Epidemiology in Mental Health : CP & EMH·Addishiwet Fantahun Adamu, Yohannes Mehretie Adinew
Jul 13, 2019·Platelets·Renee Eslick, Claire McLintock

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Related Papers

World Journal of Gastroenterology : WJG
Maria Rosa BiaginiCalogero Surrenti
European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery
E LaxdalS Aune
European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery
E LaxdalS Aune
© 2021 Meta ULC. All rights reserved