Negative correlation between serum uric acid and kidney URAT1 mRNA expression caused by resveratrol in rats

Molecular Nutrition & Food Research
Cheng-Tse LeePei-Fung Wu

Abstract

This study established a hyperuricemic rat model to elucidate the effect of resveratrol on the transport of UA in the kidney. Hyperuricemia was induced in rats through daily oral gavage of a potassium oxonate and UA mixture over 3 weeks. Our results revealed that resveratrol significantly reduced the serum UA levels but not creatinine, c-creative protein, alanine aminotransferase, or aspartate aminotransferase levels in these rats. Furthermore, renal URAT1 and OAT1 mRNA expression were significantly higher in the rats treated with allopurinol than in those with no treatment. Therefore, allopurinol not only inhibited UA production but also mediated renal URAT1 and OAT1 expression. The correlation analysis revealed that UA levels correlated negatively with renal IL-6 mRNA expression in rats treated with allopurinol. Moreover, URAT1 showed strong immunoreactivity in the distal convoluted tubule of rats treated with allopurinol or resveratrol and in hyperuricemic treated with allopurinol. Finally, in the rats treated with resveratrol, UA levels correlated negatively with renal URAT1 mRNA expression; thus, resveratrol reduced URAT1 mRNA expression under high UA levels, thereby reducing UA reabsorption in renal cells. Resveratrol con...Continue Reading

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Citations

Dec 28, 2017·Critical Reviews in Food Science and Nutrition·Arshad MehmoodAmjad Abbas Shah
Apr 11, 2019·Current Pharmaceutical Design·Tanzir RafeMd Abu Taher Sagor
Aug 25, 2021·Journal of Food Biochemistry·Fengmao ZouFuqi Wang

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