Abstract
The aim of this prospective observational study was to assess the incidence and pattern of hypopituitarism after diffuse axonal injury (DAI) and to identify its effect on these patients in terms of functional outcome. Of 1307 patients with traumatic brain injury treated at the authors' institution between March 2005 and June 2008, 65 patients with DAI were enrolled in the present study. The authors determined basal hormone levels, initial Glasgow Coma Scale scores, the Marshall CT grades, the presence of abnormal signal intensity indicating lesions on MR images, and duration of unconsciousness. At the 6-month follow-up visits, functional outcomes were estimated using the Modified Barthel Index. Univariate and multivariate analyses were performed to identify factors that influenced functional outcomes. Twenty-one patients with hypopituitarism (Group A) had more lesions in the body of the corpus callosum, basal ganglia, thalamus, and the gray-white matter junction than those without hypopituitarism (Group B). In Group A, growth hormone deficiency (17 patients, 80.9%) was the most common, and multiple pituitary hormone deficiencies were found in 12 patients (57.1%). The mean Modified Barthel Index score at the 6-month follow-up wa...Continue Reading
References
Jun 1, 1991·Journal of Neurology, Neurosurgery, and Psychiatry·J H AdamsW L Maxwell
Jul 1, 1989·Histopathology·J H AdamsD R McLellan
Jul 13, 1974·Lancet·G Teasdale, B Jennett
Jan 1, 1971·Brain : a Journal of Neurology·M R Crompton
Apr 1, 1981·Journal of Neurology, Neurosurgery, and Psychiatry·B JennettN Brooks
Dec 1, 1982·Annals of Neurology·T A GennarelliR P Marcincin
Aug 1, 1995·Journal of Neurotrauma·P C BlumbergsA J McLean
Aug 1, 1995·Journal of Neurotrauma·D F MeaneyT A Gennarelli
Aug 6, 2000·Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi·H KusanagiA Teramoto
Apr 19, 2000·The Journal of Clinical Endocrinology and Metabolism·S BenvengaF Trimarchi
Oct 14, 2000·Ryōikibetsu shōkōgun shirīzu·T Mitsuma, Y Hirooka
Nov 4, 2000·Journal of Neurosurgery·D F KellyC Wang
Jun 19, 2001·Lancet·J Springer, A Chollet
Sep 25, 2002·European Radiology·K HerganT A G M Huisman
Jul 1, 1961·Annals of Internal Medicine·R ALTMAN, W PRUZANSKI
Aug 13, 2005·Brain Injury : [BI]·R J UrbanB Masel
Oct 1, 2005·Brain Injury : [BI]·E GhigoR Urban
Mar 2, 2006·Pituitary·Monica LorenzoFelipe F Casanueva
Sep 5, 2006·Acta Radiologica·Y EzakiI Nagata
May 10, 2007·Brain Injury : [BI]·Ken SugiyamaShin-Ichi Izumi
Aug 7, 2007·British Journal of Neurosurgery·V F J NewcombeD K Menon
Citations
Oct 14, 2011·Journal of Neurotrauma·Odile Kozlowski MoreauMarc Rousseaux
Nov 6, 2012·Journal of Neurotrauma·Trandur UlfarssonMichael Nilsson
Feb 26, 2013·World Neurosurgery·Viraat HarshAnil Kumar
Jun 12, 2012·Annales Françaises D'anesthèsie Et De Rèanimation·S Ciancia
Jul 15, 2015·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Charles W Wilkinson
Feb 14, 2015·Journal of Neurosurgery·Ping ZhengWusong Tong
Jan 15, 2015·European Journal of Endocrinology·Chris J GardnerDaniel J Cuthbertson
May 23, 2012·The Journal of Head Trauma Rehabilitation·Emily R RosarioDavid Patterson
May 8, 2015·Endocrine Reviews·Fatih TanriverdiFahrettin Kelestimur
Nov 20, 2013·Critical Care Medicine·François LauzierDeborah Cook
May 22, 2019·Journal of Neurotrauma·John A EmelifeonwuPeter J D Andrews
Nov 5, 2016·Frontiers in Neurology·Rita de Cássia Almeida VieiraRegina Márcia Cardoso de Sousa
Mar 29, 2020·Brain Injury : [BI]·Marleen Maria van EijckGerwin Roks
Nov 20, 2020·Neuropsychiatric Disease and Treatment·Guojin XiaYanxing Guan
Apr 2, 2021·Frontiers in Endocrinology·Valentina GascoSilvia Grottoli
Jun 19, 2021·World Journal of Emergency Medicine·Gui-Long FengXiao Zhang