Negative effect of hypopituitarism following brain trauma in patients with diffuse axonal injury

Journal of Neurosurgery
Jae Hyun JeongJoon Soo Kim

Abstract

The aim of this prospective observational study was to assess the incidence and pattern of hypopituitarism after diffuse axonal injury (DAI) and to identify its effect on these patients in terms of functional outcome. Of 1307 patients with traumatic brain injury treated at the authors' institution between March 2005 and June 2008, 65 patients with DAI were enrolled in the present study. The authors determined basal hormone levels, initial Glasgow Coma Scale scores, the Marshall CT grades, the presence of abnormal signal intensity indicating lesions on MR images, and duration of unconsciousness. At the 6-month follow-up visits, functional outcomes were estimated using the Modified Barthel Index. Univariate and multivariate analyses were performed to identify factors that influenced functional outcomes. Twenty-one patients with hypopituitarism (Group A) had more lesions in the body of the corpus callosum, basal ganglia, thalamus, and the gray-white matter junction than those without hypopituitarism (Group B). In Group A, growth hormone deficiency (17 patients, 80.9%) was the most common, and multiple pituitary hormone deficiencies were found in 12 patients (57.1%). The mean Modified Barthel Index score at the 6-month follow-up wa...Continue Reading

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Citations

Oct 14, 2011·Journal of Neurotrauma·Odile Kozlowski MoreauMarc Rousseaux
Feb 26, 2013·World Neurosurgery·Viraat HarshAnil Kumar
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Nov 5, 2016·Frontiers in Neurology·Rita de Cássia Almeida VieiraRegina Márcia Cardoso de Sousa
Jun 19, 2021·World Journal of Emergency Medicine·Gui-Long FengXiao Zhang

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Methods Mentioned

BETA
hormone replacement therapy

Software Mentioned

SPSS

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