Negative effect of zoledronic acid on tendon-to-bone healing

Acta Orthopaedica
Geir Aasmund HjorthaugSigbjorn Dimmen

Abstract

Background and purpose - Outcome after ligament reconstruction or tendon repair depends on secure tendon-to-bone healing. Increased osteoclastic activity resulting in local bone loss may contribute to delayed healing of the tendon-bone interface. The objective of this study was to evaluate the effect of the bisphosphonate zoledronic acid (ZA) on tendon-to-bone healing. Methods - Wistar rats (n = 92) had their right Achilles tendon cut proximally, pulled through a bone tunnel in the distal tibia and sutured anteriorly. After 1 week animals were randomized to receive a single dose of ZA (0.1 mg/kg IV) or control. Healing was evaluated at 3 and 6 weeks by mechanical testing, dual-energy X-ray absorptiometry and histology including immunohistochemical staining of osteoclasts. Results - ZA treatment resulted in 19% (95% CI 5-33%) lower pullout strength and 43% (95% CI 14-72%) lower stiffness of the tendon-bone interface, compared with control (2-way ANOVA; p = 0.009, p = 0.007). Administration of ZA did not affect bone mineral density (BMD) or bone mineral content (BMC). Histological analyses did not reveal differences in callus formation or osteoclasts between the study groups. Interpretation - ZA reduced pullout strength and stiff...Continue Reading

References

Mar 30, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·C LiH Norimatsu
Jun 1, 2002·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Matthew J SilvaRichard H Gelberman
Aug 2, 2005·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·L M GalatzS Thomopoulos
Sep 6, 2005·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Negin AmanatDavid G Little
Mar 4, 2006·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Matthew J SilvaRichard H Gelberman
Jan 6, 2007·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Stavros ThomopoulosMatthew J Silva
Mar 21, 2007·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Negin AmanatDavid Little
Oct 3, 2007·The Journal of Bone and Joint Surgery. American Volume·Scott A RodeoLiang Ying
Oct 9, 2007·Clinics in Sports Medicine·Lawrence V Gulotta, Scott A Rodeo
Jan 25, 2008·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·R G G RussellM J Rogers
Jul 18, 2008·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Max EkdahlFreddie H Fu
Feb 5, 2009·The Journal of Bone and Joint Surgery. British Volume·S DimmenJ E Madsen
Sep 22, 2010·Journal of Materials Science. Materials in Medicine·Therese AnderssonPentti Tengvall
Aug 5, 2011·The American Journal of Sports Medicine·Seok Won ChungSae Hoon Kim
Nov 5, 2014·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Geir Aasmund HjorthaugSigbjorn Dimmen
Oct 21, 2015·Advanced Drug Delivery Reviews·Lisa E ColeRyan K Roeder
Feb 16, 2016·Eklem hastalıkları ve cerrahisi = Joint diseases & related surgery·Mehmet TürkerMahi Balcı

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Citations

Jan 14, 2020·BMC Musculoskeletal Disorders·Chang-Meen SungHyung Bin Park

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Methods Mentioned

BETA
pullout
light microscopy

Software Mentioned

SPSS® Statistics
Lunar PIXImus

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