Negative effects of a low-quality protein diet on wound healing via modulation of the MMP2 activity in rats

Amino Acids
Takumi YamaneYuichi Oishi

Abstract

Protein malnutrition is largely associated with a delay or failure of the healing process. However, the effect of dietary protein quality on wound healing is largely unknown. This study aimed to reveal the effect of dietary protein quality on wound healing and elucidate the regulatory mechanisms in a rat model of full-thickness cutaneous wounds. Rats were fed a normal diet for a week, and then they were divided into three groups that were fed the following diet for the experimental period: casein diet, gluten diet and gluten + lysine diet. The gluten diet significantly decreased body weight and wound healing compared with the casein diet, but this effect was reversed by supplementation with lysine. The numbers of leukocytes were significantly higher in the skin of the gluten group than those in the casein group. The wounded skin tissues of the gluten group showed lower amounts of collagen deposition compared with that in the casein group. Our results also showed that both matrix metalloproteinase (MMP) 2 activity and MMP14 mRNA levels were significantly increased in the skin of the gluten group, compared with the casein group. In summary, this study suggests low-quality protein diets have negative effects on wound healing via m...Continue Reading

References

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Dec 14, 2018·Current Dermatology Reports·Samantha EllisDanielle Tartar

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Citations

Oct 23, 2020·Journal of Cosmetic Dermatology·Antonio ScaranoDomenico Amuso
Sep 10, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Taichi GotoMichael J Iadarola

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Methods Mentioned

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protein assay
PCR
zymography

Software Mentioned

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