Negative feedback and modern anti-cancer strategies targeting the ER stress response.

FEBS Letters
Yaofu LiuYili Yang

Abstract

Endoplasmic reticulum (ER) stress is a cell state in which misfolded or unfolded proteins are aberrantly accumulated in the ER. ER stress induces an evolutionarily conserved adaptive response, named the ER stress response, that deploys a self-regulated machinery to maintain cellular proteostasis. However, compared to its well-established canonical activation mechanism, the negative feedback mechanisms regulating the ER stress response remain unclear and no accepted methods or markers have been established. Several studies have documented that both endogenous and exogenous insults can induce ER stress in cancer. Based on this evidence, small molecule inhibitors targeting ER stress response have been designed to kill cancer cells, with some of them showing excellent curative effects. Here, we review recent advances in our understanding of negative feedback of the ER stress response and compare the markers used to date. We also summarize therapeutic inhibitors targeting ER stress response and highlight the promises and challenges ahead.

References

Oct 1, 1992·The Journal of Cell Biology·T Noda, M G Farquhar
Dec 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·H NagaiT Yura
Jan 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·J SiekierkaS Ochoa
Feb 1, 1996·The Journal of Cell Biology·A A McCracken, J L Brodsky
Oct 1, 1995·Bioscience Reports·T B RogersW J Lederer
Feb 15, 2003·Developmental Cell·Hiderou YoshidaKazutoshi Mori
Oct 16, 2003·Molecular and Cellular Biology·Ann-Hwee LeeLaurie H Glimcher
May 29, 2004·EMBO Reports·Balasubrahmanyam MedicherlaDieter H Wolf
Jun 11, 2004·Annual Review of Biochemistry·Ari Helenius, Markus Aebi
Dec 8, 2005·Neoplasia : an International Journal for Oncology Research·Monica CattaneoIda Biunno
Nov 10, 2007·Science·Jonathan H LinPeter Walter
Feb 13, 2008·Laboratory Investigation; a Journal of Technical Methods and Pathology·Nicole RauschertH Peter Vollmers
Jun 24, 2008·Molecular Cell·Yongjie WeiBeth Levine
Jul 25, 2008·Proceedings of the National Academy of Sciences of the United States of America·Denis M Schewe, Julio A Aguirre-Ghiso
Nov 13, 2008·Nature Reviews. Molecular Cell Biology·Shruthi S Vembar, Jeffrey L Brodsky
Feb 18, 2009·BMC Immunology·Diana P GranadosClaude Perreault
May 30, 2009·Antioxidants & Redox Signaling·Feras Hatahet, Lloyd W Ruddock

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