Negative feedback mechanism suppresses interleukin-12 production by antigen-presenting cells interacting with T helper 2 cells

European Journal of Immunology
A Hino, H Nariuchi

Abstract

Interleukin-12 (IL-12) has been shown to be produced by monocytes by the ligation of CD40. In the present experiments, IL-12 is shown to be produced by murine spleen antigen-presenting cells (APC) by interaction with T helper 1 (Th1) clones through CD40-CD40 ligand (CD40L) interaction, but not with Th2 clones. The IL-12 production induced by the Th1 clone interaction was inhibited by the addition of exogenous IL-10. Th2 clones were shown to produce a sufficient amount of IL-10 to inhibit the IL-12 production induced by Th1 clones. In the presence of anti-IL-10 monoclonal antibodies splenic APC interacting with Th2 clones produced IL-12. These results indicate that IL-10 produced by Th2 cells stimulated with antigen suppress IL-12 production of APC interacting with Th2 cells. IL-12 is composed of two subunits, p35 and p40. In our experiments, p40 mRNA accumulation was shown to be affected by IL-10 more severely than the accumulation of p35 mRNA, indicating that IL-10 regulates IL-12 production by APC mainly by affecting p40 mRNA accumulation.

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Citations

Jun 30, 1998·European Journal of Immunology·F RiaL Adorini
Dec 24, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Y YamaguchiM Ogawa
Mar 25, 2004·The American Journal of Pathology·Ayako HinoHiroshi Kiyono
Jul 29, 2009·The Journal of Experimental Medicine·Leona GabrysováDavid C Wraith
Mar 1, 1997·American Journal of Reproductive Immunology : AJRI·P C ArckD A Clark
May 1, 1997·European Journal of Immunology·T De SmedtM Moser
Dec 20, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·A G PaulR van der Zee
May 21, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ayako HinoHiroshi Kiyono
Nov 27, 2016·Seminars in Immunopathology·Christopher Sie, Thomas Korn

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