Negative health implications of sickle cell trait in high income countries: from the football field to the laboratory

British Journal of Haematology
Nigel S KeyVimal K Derebail

Abstract

Worldwide, sickle cell trait is a highly prevalent gene carrier state. While generally a benign condition with a normal life expectancy, it is becoming increasingly clear that the sickle trait is associated with certain adverse outcomes. This article will focus on three of these outcomes, namely exertional rhabdomyolysis and sudden death, chronic renal dysfunction, and venous thromboembolism. In each case, the epidemiological evidence for the association is reviewed, together with the existing data on potential underlying mechanisms. Because newborn screening programmes for sickle cell anaemia also identify those with sickle cell trait, it is imperative that further studies determine what, if any, preventive measures can be taken to reduce the burden of these uncommon but potentially morbid complications in affected individuals.

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Citations

Oct 30, 2015·British Journal of Haematology·Chirag AminNigel S Key
Dec 8, 2015·Hematology·Rakhi P Naik, Carlton Haywood
Mar 7, 2017·Nursing·Vincent M Vacca, Lora Blank
Dec 8, 2015·Hematology·Venée N Tubman, Joshua J Field
Jan 1, 2020·British Journal of Haematology·Scott HansenJohn M Higgins
Feb 18, 2020·British Journal of Haematology·Samuel WilsonNigel S Key
Mar 18, 2020·British Journal of Haematology·Sarah SkinnerDominique Sigaudo-Roussel
May 14, 2020·Clinical Pediatrics·William PrimackStephanie Jernigan
Mar 13, 2019·British Journal of Haematology·Jiaqi HuLianne M Kurina
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Sep 29, 2021·Blood Advances·Lauren E MerzMaureen O Achebe
Oct 12, 2021·European Journal of Applied Physiology·K ReminyS Antoine-Jonville

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